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Evolving perspectives on aortic stenosis: the increasing importance of evaluating the right ventricle before aortic valve intervention.
Front Cardiovasc Med
January 2025
School of Cardiovascular Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Aortic stenosis (AS) was historically considered a disease of the left side of the heart, with the main pathophysiological impact being predominantly on the left ventricle (LV). However, progressive pressure overload in AS can initiate a cascade of extra-valvular myocardial remodeling that could also precipitate maladaptive alterations in the structure and function of the right ventricle (RV). The haemodynamic and clinical importance of these changes in patients with AS have been largely underappreciated in the past.
View Article and Find Full Text PDFExosomes and non-coding RNAs: Exploring their roles in human myocardial dysfunction.
Biomed Pharmacother
January 2025
Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland; Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland; Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, USA; Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic. Electronic address:
Myocardial dysfunction, characterized by impaired cardiac muscle function, arises from diverse etiologies, including coronary artery disease, myocardial infarction, cardiomyopathies, hypertension, and valvular heart disease. Recent advancements have highlighted the roles of exosomes and non-coding RNAs in the pathophysiology of myocardial dysfunction. Exosomes are small extracellular vesicles released by cardiac and other cells that facilitate intercellular communication through their molecular cargo, including ncRNAs.
View Article and Find Full Text PDF[Résultats chirurgicaux prometteurs à long terme du remplacement valvulaire aortique chez les patients présentant une régurgitation aortique isolée importante et une dysfonction ventriculaire gauche sévère].
Ann Cardiol Angeiol (Paris)
January 2025
Cardiology A Department, Ibn Sina Hospital, Mohammed V University, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Article Synopsis
- The study focuses on the outcomes of aortic valve replacement (AVR) in young Moroccan patients with severe aortic regurgitation and impaired left ventricle function.
- A total of 42 out of 110 patients with significant aortic regurgitation and an ejection fraction of ≤35% underwent AVR, showing a low immediate postoperative mortality rate of 4.7%.
- Long-term follow-up indicated a high survival rate of 86.8% after 15 years, along with significant clinical improvements and increased left ventricle ejection fraction post-surgery.
Study protocol for an international registry observational study evaluating clinical outcomes of transcatheter versus standard surgical mitral valve operation for secondary mitral regurgitation: the TEERMISO study.
BMJ Open
January 2025
Department of Cardiac Surgery, Assistance Publique-Hôpitaux de Paris, Creteil, France.
Background: Secondary mitral regurgitation (SMR) is a condition affecting the left ventricle (LV) rather than the mitral valve (MV). If the MV remains structurally unchanged, enlargement of the LV or impairment of the papillary muscles can occur. Several mechanical interventions are available to dictate the resolution of MR.
View Article and Find Full Text PDFThe role of multimodality imaging in diabetic cardiomyopathy: a brief review.
Front Endocrinol (Lausanne)
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Diabetic cardiomyopathy (DMCM), defined as left ventricular dysfunction in the setting of diabetes mellitus without hypertension, coronary artery disease or valvular heart disease, is a well-recognized entity whose prevalence is certainly predicted to increase alongside the rising incidence and prevalence of diabetes mellitus. The pathophysiology of DMCM stems from hyperglycemia and insulin resistance, resulting in oxidative stress, inflammation, cardiomyocyte death, and fibrosis. These perturbations lead to left ventricular hypertrophy with associated impaired relaxation early in the course of the disease, and eventually culminating in combined systolic and diastolic heart failure.
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