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Effect of Meperidine on Equine Blood Histamine, Tryptase, and Immunoglobulin-E Concentrations.
Front Vet Sci
December 2020
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
To evaluate changes in immunological parameters following subcutaneous (SC) and intramuscular (IM) administration of meperidine in horses through quantitative analysis of plasma tryptase, histamine, and IgE levels. Six adult horses were enrolled in a prospective randomized crossover design. Horses were administered one treatment per day, with a seven day washout period: (a) meperidine 1 mg/kg IM, saline 6 mL SC; (b) saline 6 mL IM, meperidine 1 mg/kg SC; (c) saline 6 mL SC, saline 6 mL IM.
View Article and Find Full Text PDFPharmacokinetics and pharmacodynamics of meperidine after intramuscular and subcutaneous administration in horses.
Vet Surg
February 2021
K. L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California.
Objective: To describe the pharmacokinetics and pharmacodynamics of meperidine after IM and subcutaneous administration in horses.
Study Design: prospective, randomized, blinded, crossover trial.
Animals: Six adult horses weighing 494 ± 33 kg.
Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.
BMC Vet Res
October 2020
K.L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California-Davis, CA, 95616, Davis, USA.
Background: Meperidine is a synthetic opioid that belongs to the phenylpiperidine class and is a weak mu receptor agonist. In horses there are a limited number of published studies describing the analgesic effects of systemically administered meperidine in horses. The objective of this study was to describe the pharmacokinetics, behavioral and physiologic effects and effect on thermal threshold of three doses of intravenously administered meperidine to horses.
View Article and Find Full Text PDFPartial intravenous anaesthesia in the horse: a review of intravenous agents used to supplement equine inhalation anaesthesia. Part 2: opioids and alpha-2 adrenoceptor agonists.
Vet Anaesth Analg
January 2015
Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Objective: To review the literature with regard to the use of different intravenous agents as supplements to inhalational anaesthesia in horses. The Part 2 of this review will focus in the use of opioids and α2 -agonists.
Databases Used: Pubmed and Web of Science.
Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses.
Equine Vet J Suppl
December 2013
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, USA.
Reasons For Performing Study: There are no peer reviewed, blinded controlled studies regarding the skeletal analgesic efficacy of intramuscularly administered meperidine in horses.
Objectives: Using an adjustable heart bar shoe model of equine foot pain, the objective of this study was to test the hypothesis that meperidine (pethidine) administered intramuscularly would prove more efficacious in alleviating lameness than a saline placebo.
Study Design: Crossover pharmacodynamic experiment.
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