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A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy.
Implement Sci Commun
January 2025
Center for Dissemination and Implementation Science, Northwestern University Feinberg School of Medicine, 633 N St Clair Street, Chicago, IL, USA.
Background: Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based practice that can identify adolescents who use alcohol and other drugs and support proper referral to treatment. Despite an American College of Surgeons mandate to deliver SBIRT in pediatric trauma care, trauma centers throughout the United States have faced numerous patient, provider, and organizational level barriers to SBIRT implementation. The Implementing Alcohol Misuse Screening, Brief Intervention, and Referral to Treatment Study (IAMSBIRT) aimed to implement SBIRT across 10 pediatric trauma centers using the Science-to-Service Laboratory (SSL), an empirically supported implementation strategy.
View Article and Find Full Text PDFSEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation.
Nat Commun
January 2025
Department of Biological Sciences, Columbia University, New York, NY, USA.
A protein's molecular interactions and post-translational modifications (PTMs), such as phosphorylation, can be co-dependent and reciprocally co-regulate each other. Although this interplay is central for many biological processes, a systematic method to simultaneously study assembly states and PTMs from the same sample is critically missing. Here, we introduce SEC-MX (Size Exclusion Chromatography fractions MultipleXed), a global quantitative method combining Size Exclusion Chromatography and PTM-enrichment for simultaneous characterization of PTMs and assembly states.
View Article and Find Full Text PDFMOF UiO-66 and its composites: design strategies and applications in drug and antibiotic removal.
Environ Sci Pollut Res Int
January 2025
Department of Chemistry, Kohsar University Murree, Murree, 47150, Punjab, Pakistan.
Antibiotics and pharmaceuticals exert significant environmental risks to aquatic ecosystems and human health. Many effective remedies to this problem have been developed through research. Metal-organic frameworks (MOFs) are potential constituents, for drug and antibiotic removal.
View Article and Find Full Text PDFCaps-ac4C: an effective computational framework for identifying N4-acetylcytidine sites in human mRNA based on deep learning.
J Mol Biol
January 2025
Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. Electronic address:
N4-acetylcytidine (ac4C) is a crucial post-transcriptional modification in human mRNA, involving the acetylation of the nitrogen atom at the fourth position of cytidine. This modification, catalyzed by N-acetyltransferases such as NAT10, is primarily found in mRNA's coding regions and enhances translation efficiency and mRNA stability. ac4C is closely associated with various diseases, including cancer.
View Article and Find Full Text PDFThe second life for unused COVID-19 vaccines: Towards biosensing application.
Talanta
January 2025
State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania; Pharmacy and Pharmacology Center, Faculty of Medicine, Vilnius University, Ciurlionio str. 21, Vilnius, Lithuania. Electronic address:
Many vaccines have been produced during the COVID-19 pandemic. Currently, an increasing number of vaccines have reached an expiration date without being used. Therefore, expired vaccines (EXVAX) based on virus-like particles (VLP) recombinant SARS-CoV2-S protein can be repurposed for biosensing application and provide a use, even though they are past their expiration date for vaccination.
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