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Thermal Adaptation of Cytosolic Malate Dehydrogenase Revealed by Deep Learning and Coevolutionary Analysis.
J Chem Theory Comput
March 2025
Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
Protein evolution has shaped enzymes that maintain stability and function across diverse thermal environments. While sequence variation, thermal stability and conformational dynamics are known to influence an enzyme's thermal adaptation, how these factors collectively govern stability and function across diverse temperatures remains unresolved. Cytosolic malate dehydrogenase (cMDH), a citric acid cycle enzyme, is an ideal model for studying these mechanisms due to its temperature-sensitive flexibility and broad presence in species from diverse thermal environments.
View Article and Find Full Text PDFSequence Diversity in the 3' Untranslated Region of Alphavirus Modulates IFIT2-Dependent Restriction in a Cell Type-Dependent Manner.
J Interferon Cytokine Res
March 2025
Department of Microbiology, Seattle School of Medicine, University of Washington, Seattle, Washington, USA.
Alphaviruses (family Togaviridae) are a diverse group of positive-sense RNA (+ssRNA) viruses that are transmitted by arthropods and are the causative agent of several significant human and veterinary diseases. Interferon (IFN)-induced proteins with tetratricopeptide repeats (IFITs) are a family of RNA-binding IFN-stimulated genes (ISGs) that are highly upregulated following viral infection and have been identified as potential restrictors of alphaviruses. The mechanism by which IFIT1 restricts RNA viruses is dependent on self and non-self-discrimination of RNA, and alphaviruses evade this recognition via their 5' untranslated region (UTR).
View Article and Find Full Text PDFBiological Activity of Biomarkers Associated With Metastasis in Osteosarcoma Cell Lines.
Cancer Med
March 2025
Universidad Autónoma del Estado de Morelos, Facultad de Medicina, Cuernavaca, Morelos, Mexico.
Introduction: Osteosarcoma, a highly aggressive bone cancer primarily affecting children and young adults, remains a significant challenge in clinical oncology. Metastasis stands as the primary cause of mortality in osteosarcoma patients. However, the mechanisms driving this process remain incompletely understood.
View Article and Find Full Text PDFMycoplasma spp. in Passeriformes in Germany.
J Wildl Dis
March 2025
Clinic for Birds, Reptiles, Amphibians and Fish, Justus-Liebig-University Giessen, Frankfurter Str. 114, 35392 Giessen, Germany.
Little is known about the significance of mycoplasmas in different free-ranging bird species. One hypothesis is that the prevalence of mycoplasmas and the influence of vocalization on reproduction are evolutionarily linked. To add another piece of information toward proving or disproving this hypothesis and obtain more information about the clinical relevance of mycoplasmas, choanal swabs from different passerine species presented to a veterinary clinic were examined for mycoplasmas using culture and Mycoplasma genus-specific PCR.
View Article and Find Full Text PDFAnalysis of single-cell and spatial transcriptomics in TNBC cell-cell interactions.
Front Immunol
March 2025
Department of Breast and Thyroid Surgery, The Affliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Triple-negative breast cancer (TNBC) is a highly malignant tumor in women, characterized by high morbidity, mortality, and recurrence rates. Although surgical treatment, radiotherapy, and chemotherapy are the mainstays of current treatment methods, the high heterogeneity of TNBC results in unsatisfactory outcomes with low 5-year survival rates. Rapid advancements in omics technology have propelled the understanding of TNBC molecular biology.
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