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Leukocyte transfusion and the development of the continuous-flow blood cell separator.
Transfus Med Rev
October 2011
The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 55, Houston, TX 77030, USA.
The treatment of anemia and thrombocytopenia with allogeneic cell transfusions is an effective and well-developed technology. However, leukocyte replacement transfusion has been frustrated by the physiology of the leukocytes. To achieve effective leukocyte replacement, the continuous-flow centrifugal blood cell separator was developed, and it soon proved to be an important instrument for separation, collection, and transfusion of all the components of the blood.
View Article and Find Full Text PDFStimulation tests for the bone marrow neutrophil pool in malignancies.
Leuk Lymphoma
January 1995
Department of Hematology L, Herlev Hospital, University of Copenhagen, Denmark.
It has been known for decades that blood neutrophilia occurs after the administration of etiocholanolone, adrenocortical steroids, and endotoxins. Neutrophil leukocytosis in general may be due to several mechanisms such as increased stimulation of the myelopoiesis, increased release from the marrow, a shift from the marginated to the circulating pool (demargination), prolongation in the peripheral half-life, and decreased migration of neutrophils from the blood to the tissue. However, the principal cause of the neutrocytosis for each of the above mentioned agents is increased release of neutrophils from the bone marrow reserves.
View Article and Find Full Text PDF[Evaluation of marrow neutrophilic reserve in normal subjects and aplastic anemia patients].
Zhonghua Yi Xue Za Zhi (Taipei)
March 1992
Department of Internal Medicine, Tri-Service General Hospital/National Defense Medical Center.
The widespread use of potent marrow suppressing drugs in malignant diseases has gained increasing importance in the functional assessment of neutrophil system. A peripheral neutrophil count of 500 cells/cumm is considered to be a good indicator of risk of bacterial infection. However, despite extreme neutropenia, infection is rare in chronic benign neutropenia patients.
View Article and Find Full Text PDFA cell fraction enriched in immature granulocytes was obtained after fractionation of human bone marrow by a three-step procedure. This fraction sediments at an average density of 1.073 and has a high content of myelocytes and metamyelocytes.
View Article and Find Full Text PDFThe direct effect of testosterone and its synthetic analogs on the maintenance of human erythroid progenitor cells (BFU-E) and GM-CFC was studied in suspension cultures. To avoid interference by serum components, the experiments were conducted in serum-free media containing insulin, transferrin, selenium, BSA, and alpha-thioglycerol. When added at concentrations between 10(-7)M and 10(-9)M, testosterone improved survival of BFU-E and GM-CFC.
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