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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes.
Int J Mol Sci
April 2023
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, 620049 Ekaterinburg, Russia.
Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to atherogenesis patterns in the context of both canonical and non-classical inflammation types. In this review, we analyze various typical phenomena and outcomes of cellular pro-inflammatory stress in atherosclerosis, as well as the role of endothelial dysfunction in local and systemic manifestations of low-grade inflammation.
View Article and Find Full Text PDFPelvic gauze packing combined with an external fixator for the treatment of unstable pelvic fractures with a huge retroperitoneal hematoma: a case report.
Ann Palliat Med
November 2020
Department of General Surgery, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Shaoxing University Shengzhou Branch, Shengzhou, China.
Pelvic fractures with retroperitoneal hematoma are frequent injuries, and there are multiple treatment options for patients. In this case, a 35-year-old female patient suffered an unstable pelvic fracture due to a car crash, accompanied by the formation of a huge retroperitoneal hematoma. The vital signs of patient were not stable.
View Article and Find Full Text PDF[Establishment and evaluation of a modified plasma protamine paracoagulation test].
Nan Fang Yi Ke Da Xue Xue Bao
September 2011
173 Clinic, 421 Hospital of PLA, Huizhou 516008, China.
Objective: To establish a modified plasma protamine paracoagulation test.
Methods: Plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-dimer (D-D) tests were performed for the plasma samples collected from 98 cases of disseminated intravascular coagulation (DIC) and 156 normal subjects. The sensitivity and specificity of the 3 tests were analyzed.
Parameters were studied characterising the system of blood aggregate state control (BASC) in 693 patients with chronic gastritis and duodenitis. Suggested in the paper are six variants of the hemocoagulation and fibrinolysis inadequacy, such as latent hypercoagulation (a decline in spontaneous fibrinolysis), manifest hypercoagulation (enhanced tolerability of plasma to heparin), isolated paracoagulation (positive fibrinogen B or ethanol test), latent hypocoagulation (clot retraction is reduced or levels of fibrinogen are raised), structural hypocoagulation (spontaneous fibrinolysis is on the increase), manifest hypocoagulation (lowered tolerance of plasma to heparin). An algorithm of the BASC system is submitted allowing the diagnosis to be rendered automatic and differentiated therapy treatments to be prescribed.
View Article and Find Full Text PDF[[Methods and clinical significance of paracoagulation phenanthroline test]n].
Klin Lab Diagn
December 1996
Experiments with fibrin monomers isolated from the plasma revealed that o-phenanthroline causes the paracoagulation phenomenon. Based on this phenomenon, phenanthroline test has been developed, which enables measuring fibrin monomer and its complexes in the blood plasma. High reliability and reproducibility of this test have been confirmed in examinations of 912 patients with the DIC syndrome, thrombosis, thromboembolism, and other hemostasis disorders.
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