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Acrokeratosis paraneoplastica (Basex syndrome) with trachyonychia preceding the diagnosis of squamous cell carcinoma of the lung.
Dermatol Online J
April 2024
Department of Dermatology, Tulane University, New Orleans USA Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo USA.
Acrokeratosis paraneoplastica (Basex syndrome) is a rare paraneoplastic condition hallmarked by psoriasiform lesion development on acral surfaces, most often related to an underlying squamous cell carcinoma. Patients may also present with nail plate changes. Successful management of this condition can be accomplished by treating the underlying malignancy.
View Article and Find Full Text PDFAcrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review.
Heliyon
March 2024
Department of Legal Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.
Article Synopsis
- The skin can indicate internal diseases, with Bazex syndrome being a specific condition that shows erythematous hyperkeratosis and yellowish scales on palms and soles.
- There is a notable link between Bazex syndrome and certain cancers, particularly squamous cell carcinomas (SCC), which raises its importance in early cancer detection.
- The text presents cases of Bazex syndrome associated with SCC in the glottis and lung, while also providing insights on the disease's clinical manifestations and pathogenesis.
[Bazex syndrome: a rare paraneoplastic disease].
Medicina (B Aires)
January 2024
Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Bazex syndrome is a paraneoplastic disorder most commonly linked to squamous cell carcinomas of the upper aerodigestive tract, followed by lung cancer and other malignancies. It manifests through three stages of skin involvement that mirror the tumor's progression. Remarkably, skin lesions precede tumor symptoms or diagnosis in two-thirds of cases, underscoring the crucial role of suspecting this condition as it can promptly reveal an underlying neoplasm.
View Article and Find Full Text PDFBazex Syndrome (Acrokeratosis Paraneoplastica): A Narrative Review of Pathogenesis, Clinical Manifestations, and Therapeutic Approaches.
Cureus
September 2023
Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA.
Acrokeratosis paraneoplastica, also known as Bazex syndrome, is a relatively understudied yet clinically important dermatological condition that is inextricably associated with squamous cell carcinoma, predominantly of the upper respiratory and gastrointestinal tracts. Manifesting as unique psoriasis-like cutaneous lesions, Bazex syndrome functions as an early warning signal for underlying malignancies, underscoring the urgent need for its timely diagnosis and intervention. Notwithstanding its clinical relevance, the molecular and cellular mechanisms underpinning its pathogenesis are not fully understood.
View Article and Find Full Text PDFAnnular and acral/facial dyskeratotic paraneoplastic disorders.
Clin Dermatol
November 2023
Departments pf Dermatology and of Pathology, Immunology, and Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, New Jersey, USA. Electronic address:
Article Synopsis
- Annular and acral/facial dyskeratotic paraneoplastic disorders are skin conditions linked to distant cancers but aren't direct extensions or forms of these cancers.
- The four main types include two gyrate conditions (erythema annulare centrifugum and erythema gyratum repens) and two acral/facial conditions (acrokeratosis paraneoplastic or Bazex syndrome, and tripe palms).
- These skin disorders can appear in various forms, might be associated with different causes, and require careful diagnosis to distinguish them from other diseases.
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