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Optimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics.
Front Biosci (Landmark Ed)
December 2024
Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA.
Background: Spatial-temporal control of mRNA translation in dendrites is important for synaptic plasticity. In response to pre-synaptic stimuli, local mRNA translation can be rapidly triggered near stimulated synapses to supply the necessary proteins for synapse maturation or elimination, and 3' untranslated regions (UTRs) are responsible for proper localization of mRNAs in dendrites. Although is a robust technique for analyzing RNA localization in fixed neurons, live-cell imaging of RNA dynamics remains challenging.
View Article and Find Full Text PDFComparison of Clinical and Patient Reported Outcomes in One-Sided Cruciate-Retaining Versus Other-Sided Posterior Stabilizing Protheses in Bilateral Simultaneous Total Knee Arthroplasty.
Indian J Orthop
January 2025
Station Health Organisation, Military Hospital, Jodhpur, India.
Introduction: Cruciate retaining and posterior stabilizing knee systems are frequently used in total knee replacements. Most researchers compare the results of Cruciate Retaining (CR) and Posterior Stabilizing (PS) knees with those of a control group. The results of using both knee systems in a single patient in simultaneous Total Knee Arthroplasty (TKA) have been studied less.
View Article and Find Full Text PDFA Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration.
Biochem Res Int
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Development of Research and Development, Sunshine Guojian Pharmaceutical (Shanghai) Co. Ltd., a 3SBio Inc. Company, 399 Libing Road, Shanghai 201203, China.
Age-related macular degeneration (AMD) is a severe eye disease in people aged 60 years and older. Although anti-VEGF therapies are effective in treating neovascular AMD (NvAMD) in the clinic, up to 60% of patients do not completely respond to the therapies. Recent studies have shown that blood-derived macrophages and their associated proinflammatory cytokines may play important roles in the development of persistent disease and resistance to anti-VEGF therapy.
View Article and Find Full Text PDFResearch advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells.
Oncol Res
December 2024
Department of Biology, College of Science, Sultan Qaboos University, Muscat, 123, Oman.
Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously.
View Article and Find Full Text PDFOptimizing population mean estimation in stratified sampling using linear cost: A simulation study.
Heliyon
December 2024
Department of Mathematics, Bahria Foundation College, Peshawar Road Campus, Rawalpindi, Pakistan.
Improving efficiency has long been a focal challenge in sampling literature. However, simultaneously enhancing estimator efficacy and optimizing survey costs is a practical necessity across various fields such as medicine, agriculture, and transportation. In this study, we present a comprehensive family of generalized exponential estimators specifically designed for estimating population means within stratified sampling frameworks.
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