Similar Publications
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation.
Stem Cell Reports
February 2025
Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK; Consortium for Mitochondrial Research, UCL, Gower Street, London WC1E 6BT, UK. Electronic address:
Mutations in mitochondrial DNA cause severe multisystem disease frequently associated with muscle weakness. The m.3243A>G mutation is the major cause of mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS).
View Article and Find Full Text PDFTwenty-five years of blood flow restriction training: What we know, what we don't, and where to next?
J Sports Sci
March 2025
Graduate School of Health and Sports Science, Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan.
Blood flow restriction is a technique that involves inflating a cuff at the proximal portion of the limb with the goal of reducing arterial inflow into the muscle and venous outflow from the muscle. Low-load or low-intensity exercise in combination with blood flow restriction has been consistently shown to augment adaptations over the same/similar exercise without restriction, with changes in muscle size and strength being two of the most commonly measured adaptations. The purpose of this manuscript is to provide an updated narrative review on blood flow restriction.
View Article and Find Full Text PDFUnveiling Gestational Diabetes: An Overview of Pathophysiology and Management.
Int J Mol Sci
March 2025
Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Gestational diabetes mellitus (GDM) is characterized by an inadequate pancreatic β-cell response to pregnancy-induced insulin resistance, resulting in hyperglycemia. The pathophysiology involves reduced incretin hormone secretion and signaling, specifically decreased glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), impairing insulinotropic effects. Pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), impair insulin receptor substrate-1 (IRS-1) phosphorylation, disrupting insulin-mediated glucose uptake.
View Article and Find Full Text PDFThe effects of blood flow restriction training on early muscle strength and mid-term knee function following anterior cruciate ligament reconstruction: a systematic review and meta-analysis.
J Orthop Surg Res
March 2025
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610075, China.
Objective: Early restoration of muscle strength and knee joint function after anterior cruciate ligament reconstruction (ACLR) is a critical goal in the rehabilitation process. Blood flow restriction training (BFRT), a low-load training method, has gained attention in musculoskeletal rehabilitation in recent years, but its specific effects in ACLR rehabilitation remain unclear.
Methods: Relevant literature up to December 20, 2024, was searched in the PubMed, Embase, Cochrane, and Web of Science databases, and study selection was performed according to PRISMA guidelines.
Reversible actuation of fibrous artificial muscle under external compression load.
Sci Rep
March 2025
Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Herein, we report hybrid fibrous artificial muscles with reversible actuation, i.e., expansion upon cooling and contraction upon heating, under external compression.
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