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Methaemalbumin: a diagnostic surrogate for methaemoglobinaemia and treatment with red cell exchange in a patient with thalassaemia.
BMJ Case Rep
March 2023
Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
A man in his 30s with alpha thalassaemia (four-alpha globin gene deletion) presented with 1 week of shortness of breath and 1 month of general malaise. Pulse oximetry monitoring revealed low peripheral oxygen saturation of approximately 80% despite maximal high-flow nasal cannula oxygen (fractional inspired oxygen 1.0-60 L/min flow).
View Article and Find Full Text PDFAbdominal Pain and Cola-Colored Serum.
Clin Chem
February 2023
Laboratory of Clinical Chemistry and Haematology, VieCuri Medical Centre, Venlo, The Netherlands.
Acute haemolysis, DIC and renal failure after transfusion of uncross-matched blood during trauma resuscitation: illustrative case and literature review.
Transfus Med
August 2018
Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada.
Aims/objectives: The aims of this study were to report a patient with acute haemolytic transfusion reaction (HTR) after transfusing uncross-matched red blood cell (RBC) units and to identify the frequency of this complication.
Background: Uncross-matched RBC units are commonly transfused in emergencies, but the frequency of acute HTR is unknown.
Methods: We describe a male stabbing victim who received three units of uncross-matched RBC units complicated by acute intravascular HTR, disseminated intravascular coagulation (DIC) and renal failure.
Cola-colored dialysate as a gastrointestinal sequelae of cardiac surgery in a patient who underwent peritoneal dialysis.
Ren Fail
March 2013
Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
The discoloration of effluent peritoneal dialysate, which is transparent in origin, is seen in some particular conditions including chyloperitoneum, calcium channel blocker usage, hemoperitoneum, perforated cholecystitis, iron administration, and hemorrhagic pancreatitis. We report a case of a 60-year-old woman who underwent peritoneal dialysis for 3 years and presented with conspicuous cola-colored (brownish-black) dialysate after a cardiac surgery. The findings of the dialysate analysis and the abdominal computed tomography showed that this discoloration could be due to the presence of methemalbumin caused by pancreatitis (not hemorrhagic) combined with intra-abdominal bleeding-both of which are rare gastrointestinal complications of cardiac surgery.
View Article and Find Full Text PDFA highly effective test-system for quantitative characterization of the total antioxidant activity (TAA) of human blood serum (HBS), including methemalbumin (MetHa) as biocatalyst, H2O2 as the oxidant, o-phenylenediamine (PDA) as the acceptor of radicals and 2,2,5,7,8-pentamethylchroman-6-ol (PMC) as the inhibitor-calibrator, has been developed and proved under the laboratory environments. The test-system has been optimized for the concentrations of all the components, the reaction conditions and the PDA consumption monitoring at 37 degrees C in the medium of buffered physiological solution, pH 7.4 containing 5% DMFA and 0.
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