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The Promising Role of Plant-Derived Lectins in Oral Cancer Therapeutics: A Systematic Review.
Cureus
December 2024
Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai, IND.
Oral cancer (OC) continues to pose a significant global health challenge, marked by high morbidity and mortality rates despite advances in diagnosis and treatment. Numerous novel potential anticancer drugs have been evaluated, many of which are derived from natural sources, such as microorganisms, plants, and animals. Among these, plant lectins - a distinctive group of proteins and glycoproteins with strong biological activity - have garnered considerable attention over the years.
View Article and Find Full Text PDFTrends in the analysis of abrin poisoning for forensic purposes.
J Forensic Leg Med
August 2023
Department of Forensic Science, Punjabi University, Patiala, Punjab, India. Electronic address:
Abrus precatorius is a poisonous plant known since ancient times. Accidental poisoning is more common due to the intake of plant seeds containing deadly abrin which is a highly toxic and a thermolabile plant toxalbumin. Abrin has also been reported to be a potential chemical agent that can be used as bioweapon in military or terrorism.
View Article and Find Full Text PDFCharacterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning.
Toxins (Basel)
September 2022
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 74100, Israel.
Article Synopsis
- Abrin, a toxic protein from the rosary pea plant, is similar to ricin and both disrupt cellular protein synthesis, leading to cell death and severe lung inflammation when inhaled.
- While both toxins have similar disease progression, postexposure treatments show that mice are more effectively protected against abrin than ricin.
- The study found that abrin causes less overall lung damage compared to ricin, particularly in nonhematopoietic cells, allowing for better tissue integrity and improved results from antibody treatment after exposure.
Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway.
Environ Toxicol Pharmacol
July 2022
Division of Pharmacology & Toxicology, Defence Research Development & Establishment, Defence Research Development Organization, Gwalior 474002, India.
Article Synopsis
- Abrin, a highly toxic substance from Abrus precatorius seeds, poses a significant threat as a bio-warfare agent and leads to severe liver damage.
- Silibinin shows potential therapeutic properties, including antioxidant and anti-inflammatory effects, but its efficacy against abrin toxicity was previously unknown.
- This study reveals that silibinin can enhance survival in mice exposed to abrin by restoring liver function and reducing damage, inflammation, and signaling associated with liver cell death.
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