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Cys44 of SARS-CoV-2 3CL affects its catalytic activity.
Int J Biol Macromol
January 2025
Department of Chemical Sciences, University of Naples "Federico II", Via Cintia, 21, 80126 Napoli, Italy; CEINGE Advanced Biotechnologies s.c.a r.l. "Franco Salvatore", Via Gaetano Salvatore 486, 80131 Napoli, Italy. Electronic address:
SARS-CoV-2 encodes a 3C-like protease (3CL) that is essential for viral replication. This cysteine protease cleaves viral polyproteins to release functional nonstructural proteins, making it a prime target for antiviral drug development. We investigated the inhibitory effects of halicin, a known c-Jun N-terminal kinase inhibitor, on 3CL.
View Article and Find Full Text PDFParoxysmal sympathetic hyperactivity: A common consequence of traumatic brain injury.
Auton Neurosci
January 2025
Department of Medicine, Jinnah Sindh Medical University, Rafiqi H J Shaheed Road, Karachi, Pakistan. Electronic address:
Paroxysmal Sympathetic Hyperactivity (PSH) is a challenging and often underrecognized syndrome, commonly arising after a traumatic brain injury (TBI). Characterized by episodic bursts of heightened sympathetic activity, PSH presents with a distinct constellation of symptoms including hypertension, tachycardia, hyperthermia, and diaphoresis. While the exact pathophysiology remains elusive, current evidence suggests that the syndrome results from an imbalance between excitatory and inhibitory neuronal pathways within the central nervous system, leading to dysregulated autonomic responses.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary.
Background: Growing evidence suggests that the imbalance between excitability and inhibitory neural activity is a key aspect of cognitive decline. Subclinical epileptiform activity (SEA) has been indicated as a marker of increased cortical excitability. While SEA is considered as a benign EEG sign in the elderly population, recent studies demonstrated its role in the progression of Alzheimer's disease.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, Cologne, North-rhine westphalia, Germany.
Background: Alzheimer's disease (AD) presents a prolonged asymptomatic phase, providing a significant timeframe for potential intervention. Leveraging this opportunity necessitates the early identification of diagnostic and prognostic biomarkers to detect Alzheimer's pathology during predementia stages. This enables the identification of individuals likely to progress to Alzheimer's-type dementia, allowing them to benefit from targeted disease-modifying therapies.
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Alzheimers Dement
December 2024
University of Illinois Urbana-Champaign, Champaign, IL, USA.
Background: No study has synthesized evidence from randomized controlled trials (RCTs) testing the acute and chronic effects of reallocating sedentary time (ST) to physical activity (PA) on cognitive and brain health across the lifespan.
Method: Seven academic databases were systematically searched on October 26, 2022, with an updated search on June 23, 2023. Inclusion criteria encompassed RCTs published in English involving healthy participants aged ≥ 4 years.
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