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A study on the optimal safety speed and warning sign distance for highways in windy and sandy environments based on driving behavior.
Traffic Inj Prev
January 2025
School of Civil and Hydraulic Engineering, NingXia University, YinChuan, China.
Objective: This study aims to address the issue of driving safety on highways in the desert region of Northwest China during extreme weather conditions such as sandstorms, with the goal of reducing driver risk. It explores driver behavior under extreme conditions of sandstorms and sand accumulation, proposing safety speed recommendations and warning models for different environments to calculate the optimal warning distance in windy and sandy conditions.
Methods: Natural driving simulation experiments were conducted in windy and sandy environments, collecting driving behavior data from 45 drivers under varying visibility and road conditions with or without sand accumulation.
Effects of an Inclusive Group-Based Naturalistic Developmental Behavioral Intervention on Active Engagement in Young Autistic Children: A Preliminary Study.
J Speech Lang Hear Res
January 2025
Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, Baltimore, MD.
Purpose: Despite group-level improvements in active engagement and related outcomes, significant individual variability in response to early intervention exists. The purpose of this preliminary study was to examine the effects of a group-based Naturalistic Developmental Behavioral Intervention (NDBI) on active engagement among a heterogeneous sample of young autistic children in a clinical setting.
Method: Sixty-three autistic children aged 24-60 months ( = 44.
Measuring Intentional Communication in Infants at Elevated Likelihood of Autism: Validity, Reliability, and Responsiveness of a Novel Coding Scale.
J Speech Lang Hear Res
January 2025
Program for Early Autism Research, Leadership, and Service, The University of North Carolina at Chapel Hill.
Purpose: Intentional communication acts, or purposefully directed vocalizations and gestures, are particularly difficult for infants at elevated likelihood for eventual diagnosis of autism. The ability to measure and track intentional communication in infancy thus has the potential to aid early identification and intervention efforts. This study assesses the validity of a novel measure of intentional communication intended for use within semistructured caregiver-infant interactions.
View Article and Find Full Text PDFRecalibrating Protection Factors Using Millisecond Hydrogen/Deuterium Exchange Mass Spectrometry.
Anal Chem
January 2025
School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U.K.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful technique to interrogate protein structure and dynamics. With the ability to study almost any protein without a size limit, including intrinsically disordered ones, HDX-MS has shown fast growing importance as a complement to structural elucidation techniques. Current experiments compare two or more related conditions (sequences, interaction partners, excipients, conformational states, etc.
View Article and Find Full Text PDFEarly-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models.
Sci Transl Med
January 2025
University of Strasbourg, INSERM, Strasbourg Translational Neuroscience & Psychiatry STEP-CRBS, UMR-S 1329, 67000 Strasbourg, France.
Sleep alterations have been described in several neurodegenerative diseases yet are currently poorly characterized in amyotrophic lateral sclerosis (ALS). This study investigates sleep macroarchitecture and related hypothalamic signaling disruptions in ALS. Using polysomnography, we found that both patients with ALS as well as asymptomatic and mutation carriers exhibited increased wakefulness and reduced non-rapid eye movement sleep.
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