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DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
Adv Sci (Weinh)
June 2021
Heifei National Laboratory for Physical Sciences at the Microscale of USTC, CAS Centre for Excellence in Molecular Cell Science, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230027, China.
Extracellular glutamine represents an important energy source for many cancer cells and its metabolism is intimately involved in maintaining redox homeostasis. The heightened metabolic activity within tumor tissues can result in glutamine deficiency, necessitating metabolic reprogramming responses. Here, dual mechanisms involving the stress-responsive transcription factor DDIT3 (DNA damage induced transcript 3) that establishes an interrelationship between glycolysis and mitochondrial respiration are revealed.
View Article and Find Full Text PDFβ-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice.
EMBO Mol Med
January 2019
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain
Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In the mouse model with fatal mitochondrial encephalopathy due to CoQ deficiency, we have tested the therapeutic potential of β-resorcylic acid (β-RA), a structural analog of the CoQ precursor 4-hydroxybenzoic acid and the anti-inflammatory salicylic acid.
View Article and Find Full Text PDFPseudomonas salina sp. nov., isolated from a salt lake.
Int J Syst Evol Microbiol
September 2015
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
Article Synopsis
- A new Gram-staining-negative bacterium, designated strain XCD-X85(T), was discovered in Xiaochaidan Lake in China, and it's classified within the genus Pseudomonas.
- This bacterium is non-endospore-forming, motile, and thrives in salty environments, with optimal growth conditions at 1-2% salt concentration and a temperature range of 25-30 °C.
- Genetic analysis revealed that strain XCD-X85(T) shares a high similarity to previously known species, leading to its identification as a new species, Pseudomonas salina sp. nov., with specific characteristics including unique fatty acids and a DNA G+C content of 57.4 mol%.
Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.
Biochim Biophys Acta
July 2014
Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden; Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 17176 Stockholm, Sweden.
2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cholesterol homeostasis. In light of our previous findings concerning the biological effects of certain epoxidated all-trans-polyisoprenes, the effects of squalene carrying epoxy moieties on the second and third isoprene residues were investigated here. In cultures of HepG2 cells both monoepoxides of squalene and one of their hydrolytic products inhibited cholesterol synthesis and stimulated the synthesis of coenzyme Q (CoQ).
View Article and Find Full Text PDFDietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins.
J Lipid Res
October 2013
Department of Neurosurgery, Brigham and Women's Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115.
The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat isocaloric diets. Animal growth rates and mitochondrial respiratory parameters were essentially unaffected, but mass spectrometry-based mitochondrial lipidomics profiling revealed increased levels of cardiolipins (CLs), a family of phospholipids essential for mitochondrial structure and function, in rats fed saturated or trans fat-based diets with a high glycemic index. These mitochondria showed elevated monolysocardiolipins (a CL precursor/product of CL degradation), elevated ratio of trans-phosphocholine (PC) (18:1/18:1) to cis-PC (18:1/18:1) (a marker of thiyl radical stress), and decreased ubiquinone Q9; the latter two of which imply a low-grade mitochondrial redox abnormality.
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