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Osimertinib-Induced Toxic Epidermal Necrolysis - A Case Report.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
November 2024
Faculty of Medicine, University Clinic of Radiotherapy and Oncology, Skopje, Macedonia.
Purpose: To investigate the rare side effects of Osimertinib in a case of toxic epidermal necrosis.
Case Presentation: We report on a case of a 44-year old woman with lung adenocarcinoma harboring an EGFR-sensitizing mutation who was treated with Osimertinib as the second-line treatment. Ten days after Osimertinib initiation, a diffuse erythematous rash rapidly spread over the patient's trunk along with vesicles and purpuric macules; furthermore, she developed erythema and exfoliation on the face and trunk and severe mucositis.
A rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions.
Int Immunopharmacol
January 2025
Ege University, Faculty of Medicine, Department of Pulmonary Medicine, Immunology and Allergy, Laboratory of Occupational/Environmental Respiratory Diseases and Asthma, 35100 Izmir, Türkiye; EgeSAM (Ege University Translational Pulmonary Research Center), 35100 Izmir, Türkiye. Electronic address:
Background: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is an important clinical entity that is rare and may develop with a Type IV delayed type hypersensitivity immune response to drug antigens. The incidence and characteristics of SDRIFE attributed to COronaVIrus Disease of 2019 (COVID-19) vaccines remain unclear, this issue requires further elucidation.
Objective: We aim to investigate the vaccine-related-SDRIFE and potential immunogens of COVID-19 vaccines through a literature review accompanied by a real case.
The Skin Test Predicts Clinic-Immunologic and Therapeutic Outcomes in Cutaneous Leishmaniasis.
Pathogens
November 2024
National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil.
Article Synopsis
- Cutaneous leishmaniasis (CL) is linked to a positive skin test (LST) that indicates the presence of immune T cells specific to disease antigens, with this study focusing on the differences between LST+ and LST- patients.
- LST- patients showed larger lesions, a longer duration of illness, more treatment failures with meglumine antimonate, and higher healing times compared to LST+ patients.
- The study suggests that LST- patients have an impaired Th1 immune response, characterized by higher parasite loads, lower granuloma frequency, increased CD8+ T cells, and excess Granzyme B production, leading to more severe disease.
Granulomatous Reactions From Microneedling: A Systematic Review of the Literature.
Dermatol Surg
November 2024
Meridian Dermatology, Meridian, Idaho.
Article Synopsis
- Microneedling is a popular and minimally invasive skin rejuvenation technique, but rare granulomatous reactions have been documented following the procedure.
- This study systematically reviewed existing literature and identified 13 studies involving 15 patients aged 26-74 who experienced non-necrotizing granulomatous inflammation post-procedure, often linked to motorized microneedling and Vitamin C use.
- Treatment options varied and had inconsistent success, with no clear standard approach, highlighting that these reactions can be difficult to manage.
Regulation of cell-mediated immune responses in dairy bulls via long non-coding RNAs from submandibular lymph nodes, peripheral blood, and the spleen.
Genomics
November 2024
Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China. Electronic address:
Article Synopsis
- Cell-mediated immune responses (CMIRs) in cattle are essential for a strong immune system and disease resistance, with long non-coding RNAs (lncRNAs) playing a potential regulatory role that has not been deeply studied yet.
- In a study with bulls immunized to induce delayed-type hypersensitivity, researchers categorized bulls as high or low CMIR responders based on skin reactions and identified over 21,000 lncRNAs, with specific lncRNAs showing differential expression linked to immune functions.
- The analysis revealed significant immune-related pathways associated with differentially expressed lncRNAs and suggested that these lncRNAs could serve as promising markers for studying immune responses in bovine tissues.
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