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Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism.
Medicina (Kaunas)
January 2025
Department of Nephrology, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain.
: The bite of the Loxosceles spider is a public health problem around the world, mainly in Latin America. The viscerocutaneous presentation is related to the inoculation of toxins (phospholipase-D) that generates a systemic inflammatory reaction with a subsequent increase in cytokines and chemokines. Hemoadsorption is proposed as a therapy that allows for the removal of the toxin and modulation of the inflammatory response in this disease.
View Article and Find Full Text PDFFormulation, Characterization and in vitro Release of Topical Nanoemulsion Containing Prednisolone-Derived Corticosteroid.
Drug Dev Ind Pharm
January 2025
Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Izmir, Turkey.
Backround: Prednisolone-Derived Corticosteroid (PDC), has anti-inflammatory activity in ocular administration. However, drug administration to the eye is extremely difficult due to the complex structure of the eye. Because of the ability of the eye to retain the drug and its physiology, the bioavailability of drugs applied to the eye is very low.
View Article and Find Full Text PDFFrom diagnosis to treatment: exploring the mechanisms underlying optic neuritis in multiple sclerosis.
J Transl Med
January 2025
Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during the disease course, suffering from blurred vision, pain, color vision deficits, and even blindness. Treatments have progressed from corticosteroids to therapies targeted against B/T cells.
View Article and Find Full Text PDFEnergetic costs of social dominance in wild male baboons.
Proc Biol Sci
January 2025
Department of Biology, Duke University, Durham, NC, USA.
In vertebrates, glucocorticoids can be upregulated in response to both psychosocial and energetic stressors, making it difficult to identify the cause of elevated glucocorticoid concentrations when both types of stressors are present. This problem has been particularly challenging in studies of social dominance rank in wild animals. In contrast to glucocorticoids, thyroid hormone concentrations are largely unaffected by psychosocial stressors and therefore offer a better estimate of energetic challenges.
View Article and Find Full Text PDF[Clinical guideline for the interventional treatment of gonarthrosis: Consensus and algorithms].
Rehabilitacion (Madr)
January 2025
Servicio de Medicina Física y Rehabilitación, Hospital Universitario Miguel Servet, Zaragoza, España.
Osteoarthritis is a major health problem due to its high prevalence. It is a very common cause of consultation in both primary care and hospitals, implying a high care burden and health costs. Current treatment recommendations are based on a conservative approach, based mainly on physical exercise and ultimately on prosthetic surgery.
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