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The impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or regular diet 8 weeks before breeding and throughout pregnancy and lactation. After weaning, all offspring were fed a regular diet.

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Background: Breastfeeding, acknowledged for its critical health benefits for both infants and mothers, remains markedly underutilized in Ireland, which reports the lowest breastfeeding rates in Europe. Recent data indicate that fewer than 60% of Irish mothers initiate breastfeeding at birth, with this rate precipitously declining in the subsequent weeks postpartum. Various sociocultural, psychological, and educational elements, such as prenatal breastfeeding education, influence this persistently low prevalence.

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Tobacco smoke exposure remains a significant public health concern, particularly for lactating women and their infants. Despite widespread awareness of the harms of smoking during pregnancy, many women continue to smoke postpartum, directly impacting lactation success and infant health. Studies have shown that nicotine, the primary component of tobacco smoke, inhibits prolactin production and the milk ejection reflex, resulting in a decreased milk supply and poor breastfeeding outcomes.

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Maternal diet plays a crucial role in offspring development, directly affecting neural development and gut microbiota composition. This study aimed to assess if baru almond and oil (Dipteryx alata Vog.) could modulate intestinal microbiota, brain fatty acid profile, and enhance memory in offspring of rats treated during early life stages.

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