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Cellular and biochemical alterations induced by diesel oil in the brown alga Sargassum cymosum var. stenophyllum cultured in vitro.
Chemosphere
January 2025
Plant Morphogenesis and Biochemistry Laboratory, Federal University of Santa Catarina, P. O. Box 476, 88049-900, Florianopolis, SC, Brazil. Electronic address:
The effect of the in vitro acute exposure to diesel oil (0.001%, 0.01%, 0.
View Article and Find Full Text PDFThe Protective Effect of Uridine in a Rotenone-Induced Model of Parkinson's Disease: The Role of the Mitochondrial ATP-Dependent Potassium Channel.
Int J Mol Sci
July 2024
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Russia.
The effect of the modulators of the mitochondrial ATP-dependent potassium channel (mitoK) on the structural and biochemical alterations in the substantia nigra and brain tissues was studied in a rat model of Parkinson's disease induced by rotenone. It was found that, in experimental parkinsonism accompanied by characteristic motor deficits, both neurons and the myelin sheath of nerve fibers in the substantia nigra were affected. Changes in energy and ion exchange in brain mitochondria were also revealed.
View Article and Find Full Text PDF3D human stem-cell-derived neuronal spheroids for neurotoxicity testing of methylglyoxal, highly reactive glycolysis byproduct and potent glycating agent.
Curr Res Toxicol
June 2024
Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Pavia, Italy.
Article Synopsis
- The study investigates the cytotoxic effects of methylglyoxal (MGO) on human-derived 3D neuronal spheroids, a model that mimics human brain cells, particularly in relation to aging and neurodegenerative diseases.
- Results show that MGO leads to decreased cell viability and growth at low concentrations, with significant cellular damage observed at higher doses, including necrosis and apoptosis.
- The findings highlight the potential of using these complex 3D models to evaluate the impact of MGO and other harmful agents, providing insights into mechanisms of neurodegeneration and aging.
Effects of Light Intensity on the Growth and Biochemical Composition in Various Microalgae Grown at High CO Concentrations.
Plants (Basel)
November 2023
Joint Institute for High Temperatures of the Russian Academy of Sciences, 125412 Moscow, Russia.
In modern energy, various technologies for absorbing carbon dioxide from the atmosphere are being considered, including photosynthetic microalgae. An important task is to obtain maximum productivity at high concentrations of CO in gas-air mixtures. In this regard, the aim of the investigation is to study the effect of light intensity on the biomass growth and biochemical composition of five different microalgae strains: , , , , and .
View Article and Find Full Text PDFHistory of international connections of myology in Europe.
Eur J Transl Myol
July 2023
Department of Neuroscience, University of Padova, Padua.
Over the past centuries, myology as a basic and clinical science has passed through three major stages of development: the classical period, the modern nosographic stage, and the molecular era. The classical period spans the sixteenth century up to the earlier parts of the twentieth century. During this time, several major muscle diseases were clinically and pathologically characterized, including Duchenne muscular dystrophy (DMD), myotonic dystrophy, and facio-scapulo-humeral dystrophy, by master clinicians such as Duchenne, Erb, Becker, Steinert, Landouzy, Dejerine, Meryon, and others.
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