The literature relating to the hazards of herpes simplex virus acquired by newborn infants after birth is reviewed. A total of 24 infants has been reported who have acquired the infection in this manner; 66% of these infants expired. Transmission of virus from mothers, adults (including personnel) other than the mother, and other infants has been reported. In order to prevent this infrequent but life-threatening illness, separation of the newborn infant from any person with active lesions caused by herpes simplex virus is recommended.
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