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Acute hemolytic crisis complicated with ischemic cardiac injury and methemoglobinaemia following ingestion of naphthalene: a case report.
J Med Case Rep
December 2024
Faculty of Healthcare Sciences, Eastern University of Sri Lanka, Chenkaladi, Sri Lanka.
Background: Naphthalene is an aromatic hydrocarbon that potentially produces methemoglobinaemia but rarely causes hemolysis, especially in children with underlying glucose-6-phosphate dehydrogenase deficiency. Although ingestion of a single moth ball by an older child may not be life threatening, it can be fatal if ingested by a toddler.
Case Presentation: A 2-year-old Singhalese boy developed acute severe hemolysis and methemoglobinaemia following ingestion of a mothball.
In Vitro Effects of Some Chemotherapeutics on Human Erythrocyte Glucose-6-Phosphate Dehydrogenase Enzyme.
ACS Omega
December 2024
Faculty of Veterinary Science, Department of Biochemistry, Bingöl University, Bingöl 12000, Turkiye.
In this study; the in vitro effects of some drugs used in chemotherapy on the glucose-6-phosphate dehydrogenase enzyme (G6PD; E.C. 1.
View Article and Find Full Text PDFPrevalence and screening of hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Yemeni blood donors.
Hematology
December 2024
Department of Pathology, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
Article Synopsis
- * Tests conducted included complete blood count, G6PD assay, and the NESTROF test, revealing that 21.7% of donors had hemoglobinopathies, particularly β-thalassemia trait and α-thalassemia trait.
- * The research highlighted the effectiveness of specific screening tools, showing that the NESTROF test and certain RBC indices had a sensitivity rate of 100% for identifying β-thalassemia trait, underlining the need for improved blood screening programs in Yemen
Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.
Acta Crystallogr F Struct Biol Commun
October 2024
Chemistry and Biochemistry Department, Hampton University, 200 William R. Harvey Way, Hampton, VA 23668, USA.
Article Synopsis
- Plasmodium vivax causes malaria, affecting about a third of the world's population, and primaquine treatment is unsafe for those with G6PD deficiency, which impacts a significant portion of people in endemic areas.
- The Seattle Structural Genomics Center for Infectious Disease studied PvNMT (N-myristoyltransferase) to find alternative drug targets since it's essential for P. vivax survival by facilitating protein modification.
- The newly solved crystal structure of PvNMT, showing its interaction with myristoyl-CoA and a novel inhibitor, reveals differences from human enzymes, providing insights for creating effective antimalarial drugs.
Comparative evaluation of oxidative and biochemical parameters of red cell concentrates (RCCs) prepared from G6PD deficient donors and healthy donors during RCC storage.
Transfus Clin Biol
November 2024
Department of Biochemistry, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme disorder in red blood cell (RBC). Due to the importance of G6PD enzyme as an antioxidant in RBC, we tried to investigate the oxidative damage in red cell concentrates (RCCs) prepared from donors with G6PD enzyme deficiency in comparison with healthy donors.
Material Method: This cross-sectional study was conducted on 20 male donors.
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