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Effectiveness of behavioural and psychological interventions for managing obesity in children and adolescents: A systematic review and meta-analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline.
Pediatr Obes
January 2025
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Objective: Conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) of behavioural and psychological interventions for managing paediatric obesity.
Methods: Eligible studies, published between 1985 and 2022, included 0 to 18 year olds with outcomes reported ≥3 months post-baseline, including patient-reported outcome measures (PROMs), cardiometabolic and anthropometric outcomes, and adverse events (AEs). We pooled data using a random effects model and assessed certainty of evidence (CoE) related to minimally important difference estimates for outcomes using GRADE.
Association of the Triglyceride Glucose Index With Outcomes in Acute Ischemic Stroke Injury.
Cureus
December 2024
General Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, IND.
Objectives The study aimed at estimating the triglyceride glucose (TyG) index in patients with ischemic stroke, exploring the correlation between the TyG index and the prognosis of ischemic stroke, and studying the clinical outcome in patients with acute ischemic stroke (AIS) in association with the TyG index. Methods An observational study was conducted on 105 patients with a history of AIS presenting within 24 hours. The TyG index was estimated, and the clinical outcome was studied.
View Article and Find Full Text PDFOnce-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial.
Diabetologia
January 2025
Internal Medicine Department, Endocrine Division (SEMPR), Universidade Federal do Paraná, Curitiba, Brazil.
Aims/hypothesis: COMBINE 2 assessed the efficacy and safety of once-weekly IcoSema (a combination therapy of basal insulin icodec and semaglutide) vs once-weekly semaglutide (a glucagon-like peptide-1 analogue) 1.0 mg in individuals with type 2 diabetes inadequately managed with GLP-1 receptor agonist (GLP-1 RA) therapy, with or without additional oral glucose-lowering medications.
Methods: This 52 week, randomised, multicentre, open-label, parallel group, Phase IIIa trial was conducted across 121 sites in 13 countries/regions.
Longitudinal association of statin treatment with insulin sensitivity and beta-cell function in the PROMISE cohort.
J Clin Endocrinol Metab
January 2025
Department of Physiology and Pharmacology, Western University, London, Canada.
Context: Statin treatment lowers low-density lipoprotein (LDL) cholesterol thereby reducing cardiovascular risk. Meta-analyses of clinical trials report a higher risk of new-onset type 2 diabetes with statins. Current clinical evidence regarding effects of statins on insulin sensitivity and beta-cell function is limited.
View Article and Find Full Text PDFEstimated Glucose Disposal Rate predicts the risk of incident Metabolic dysfunction-associated steatotic liver disease.
Endocr Pract
January 2025
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Objectives: There is a relationship between insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD) and the estimated glucose disposal rate (eGDR) has been reported as a surrogate marker of insulin resistance. This study aimed to investigate the association between eGDR and the incident MASLD, and compare the ability to predict incident MASLD with other insulin resistance markers.
Methods: Retrospective cohort data from a health check-up program were analyzed.
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