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Okra seed polysaccharides mitigate neuroinflammation and cognitive impairment via modulation of Nrf2/HO-1, HMGB1/RAGE/TLR4/NF-κB, NLRP3/Caspase-1, JAK-2/STAT-3, AMPK/SIRT1/m-TOR, PI3K/AKT/CREB/BDNF/TrkB and PERK/CHOP/Bcl-2 axes.
Int Immunopharmacol
January 2025
Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA. Electronic address:
Global healthcare systems are under tremendous strain due to the increasing prevalence of neurodegenerative disorders. Growing data suggested that overconsumption of high-fat/high-carbohydrates diet (HFHCD) is associated with enhanced incidence of metabolic alterations, neurodegeneration, and cognitive dysfunction. Functional foods have gained prominence in curbing metabolic and neurological deficits.
View Article and Find Full Text PDFStructural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of Abel.
Pharmaceuticals (Basel)
January 2025
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.
Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.
Enzymatic β-Mannosylation of Phenylethanoid Alcohols.
Molecules
January 2025
Institute of Chemistry, Slovak Academy of Sciences, Dúbravská Cesta 9, SK-845 38 Bratislava, Slovakia.
Phenylethanoid glycosides (PhGs) are widely occurring secondary metabolites of medicinal plants with interesting biological activities such as antioxidant, anti-inflammatory, neuroprotective, antiviral, hepatoprotective, immunomodulatory, etc. They are characterized by a structural core formed by a phenethyl alcohol, usually tyrosol or hydroxytyrosol, attached to β-D-glucopyranose via a glycosidic bond. This core is usually further decorated by attached phenolic acids or another saccharide.
View Article and Find Full Text PDFStructure Characterization and Antioxidant Activity of a Novel Polysaccharide from Fermented Millet Bran.
Foods
January 2025
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
To improve the high-value application of millet bran, a water-soluble polysaccharide was extracted from fermented millet bran (FMBP) by using fermentation. A neutral polysaccharide, FMBP-1, was separated and purified from FMBP using an anion exchange column. Its structure and antioxidant activity in vitro were characterized and determined.
View Article and Find Full Text PDFExtraction, purification, structural characterization, and anti-inflammatory activity of a polysaccharide from Lespedeza formosa.
Int J Biol Macromol
January 2025
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China; Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, the "Double-First Class" Application Characteristic Discipline of Hunan Province (Pharmaceutical Science), Changsha Medical University, Changsha 410219, China.. Electronic address:
A new acidic polysaccharide was extracted from Lespedeza Formosa (LF) using microwave-assisted extraction. After a progressive purification, Lespedeza Formosa polysaccharide (LFP-1) with 96.14 % purity and moderate molecular weight was obtained.
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