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Prognostic efficacy of lymph node parameters in resected ampullary adenocarcinoma based on long-term follow-up data after adjuvant treatment.
World J Surg Oncol
November 2024
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
Article Synopsis
- * Analyzed data from 86 patients showed that multiple LN metrics were linked to overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS), particularly highlighting the number of metastatic LNs (LNN) as a strong predictor in multivariable analysis.
- * Key findings included LNN ≥ 2 as a significant factor for OS, DFS, and DMFS, while lymph node ratio (LNR) was notable for DFS and DMFS; however, certain parameters like log odds of positive
Is pancreaticoduodenectomy justified for metastatic melanoma to the ampulla of Vater?
J Chin Med Assoc
October 2024
Division of General Surgery, Department of Surgery.
Article Synopsis
- Metastatic melanoma of the ampulla of Vater is a rare condition with 14 patient cases analyzed, primarily from cutaneous origins (73%) and presenting with jaundice (86% as a common symptom).
- The median size of the melanoma was 2.75 cm, and most patients (82%) had metastasis to other organs like the brain, lungs, and liver at diagnosis.
- Surgical interventions like pancreaticoduodenectomy, along with chemotherapy, were linked to improved survival rates, highlighting that major surgeries can still be viable options even in metastatic cases.
The clinical significance of the lymph node ratio as a recurrence indicator in ampullary cancer after curative pancreaticoduodenectomy.
Langenbecks Arch Surg
October 2024
Department of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Article Synopsis
- The study explores the importance of the lymph node ratio (LNR) in determining prognosis for patients with ampullary cancer who underwent surgical treatment between 1980 and 2018.
- Analysis of data from 106 patients revealed that higher LNR values correlated with worse outcomes, specifically linking a higher LNR to increased recurrence and lower survival rates.
- Findings suggest that LNR, particularly with an identified cut-off value of 0.07, serves as a critical independent prognostic marker for recurrence and survival in ampullary cancer patients.
ASO Author Reflections: Pancreaticoduodenectomy for Isolated Para-Aortic Lymph Node Metastasis in Non-pancreatic Periampullary Cancers: Advocating for Careful Patient Selection and Routine Frozen Section.
Ann Surg Oncol
October 2024
Division of Gastrointestinal and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.
Predicting lymph node metastasis using preoperative parameters in patients with T1 ampulla of vater cancer.
BMC Cancer
August 2024
Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Korea.
Background: Lymph node (LN) metastasis is an established prognostic factor for patients with surgically resected ampulla of Vater (AoV) cancer. The standard procedure for radical resection, including removal of regional LNs, is pancreaticoduodenectomy (PD); however, local excision has been considered as an alternative option for patients in the early stage cancer with significant comorbidities. In the present study, we elucidated the preoperative factors associated with LN metastasis to determine the appropriate surgical extent for T1 AoV cancer.
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