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Similar Publications

Successful rituximab treatment in IgG4-related coronary periarteritis: a case-based review.

Rheumatol Int

December 2024

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disorder characterized by elevated serum IgG4 levels and the enlargement and fibrosis of organs. As a rare manifestation, coronary arteries can be affected by IgG4-RD as coronary periarteritis, leading to serious complications such as stenosis or aneurysm. Although coronary periarteritis poses a life-threatening condition, optimal treatment strategies remain unclear due to its extreme rarity.

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Presented case study deals with the sudden death of a 47 years old male, shortly after a mountain bike race after reported nausea and chest pain followed by loss of consciousness and resuscitation. Cardiopulmonary resuscitation was unsuccessful. An autopsy was enacted due to the sudden death in a seemingly healthy person.

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Article Synopsis
  • The heart can be affected by a disease called IgG4-related disease (IgG4-RD), which is rare but important to study.
  • In a study of 42 patients, researchers looked at the heart problems caused by this disease and how well treatments worked.
  • Most patients responded well to treatments like glucocorticoids, but some had relapses, showing that careful monitoring is needed even after treatment.
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Accumulation of Technetium-99m Tetrofosmin on Myocardial Perfusion Scintigraphy in a Patient With Immunoglobulin G4-Related Coronary Periarteritis.

Can J Cardiol

March 2024

Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan; Department of Diagnostic Imaging, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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