Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Modelling Peroxisomal Disorders in Zebrafish.
Cells
January 2025
Biosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QD, UK.
Peroxisomes are ubiquitous, dynamic, oxidative organelles with key functions in cellular lipid metabolism and redox homeostasis. They have been linked to healthy ageing, neurodegeneration, cancer, the combat of pathogens and viruses, and infection and immune responses. Their biogenesis relies on several peroxins (encoded by genes), which mediate matrix protein import, membrane assembly, and peroxisome multiplication.
View Article and Find Full Text PDFSirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome.
Biomolecules
November 2024
Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC) that can be chain-shortened four rounds to succinyl-CoA, drives high-level protein hypersuccinylation in the peroxisome, particularly on peroxisomal FAO enzymes. However, the ability of SIRT5 to reverse DC-induced peroxisomal succinylation, or to regulate peroxisomal FAO in this context, remained unexplored.
View Article and Find Full Text PDFPeroxisomal dysfunction interferes with odontogenesis and leads to developmentally delayed teeth and defects in distinct dental cells in Pex11b-deficient mice.
PLoS One
December 2024
Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany.
Human peroxisomal biogenesis disorders of the Zellweger syndrome spectrum affect skeletal development and induce tooth malformations. Whereas several peroxisomal knockout mouse studies elucidated the pathogenesis of skeletal defects, little information is available on how dental pathologies arise in peroxisomal biogenesis disorder patients. To understand the impact of severe peroxisomal dysfunction on early odontogenesis, here we performed morphometric studies on developing molars of new-born Pex11b knockout mice.
View Article and Find Full Text PDFRedox system and ROS-related disorders in peroxisomes.
Free Radic Res
October 2024
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Article Synopsis
- Peroxisomes are crucial organelles that protect cells from oxidative damage caused by reactive oxygen species (ROS) through various antioxidant functions.
- They are involved in vital metabolic processes like α-oxidation, β-oxidation, and the synthesis of cholesterol and ether phospholipids.
- The review aims to shed light on the connection between peroxisomal metabolism and ROS-related disorders, exploring recent findings and the ongoing mysteries around these mechanisms in diseases like neurodegeneration and cancer.
Distinct peroxisome populations differentially respond to alcohol-associated hepatic injury.
Mol Biol Cell
December 2024
Department of Biology, The Catholic University of America, Washington, DC, 20064.
Although peroxisomes are known to oxidize ethanol, metabolize lipids, and regulate oxidative stress, they remain understudied in the context of ethanol-induced liver injury. We examined peroxisome early responses to alcohol-induced oxidative stress and lipid overload. Analysis of peroxisomes labeled with catalase, an ethanol oxidizing enzyme, or ABCD3, a fatty acid transporter, revealed that distinct peroxisome populations differentially respond to ethanol.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!