Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.2042-7158.1972.tb09028.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
uORF-targeting steric block antisense oligonucleotides do not reproducibly increase RNASEH1 expression.
Mol Ther Nucleic Acids
March 2025
Department of Paediatrics, University of Oxford, Headington, Oxford OX3 7TY, UK.
Upstream open reading frames (uORFs) are -regulatory motifs that are predicted to occur in the 5' UTRs of the majority of human protein-coding transcripts and are typically associated with translational repression of the downstream primary open reading frame (pORF). Interference with uORF activity provides a potential mechanism for targeted upregulation of the expression of specific transcripts. It was previously reported that steric block antisense oligonucleotides (ASOs) can bind to and mask uORF start codons to inhibit translation initiation, and thereby disrupt uORF-mediated gene regulation.
View Article and Find Full Text PDFLong-term Complications From Peripheral Nerve Blocks After Pediatric Orthopaedic Lower Extremity Procedures: A Systematic Review.
Am J Sports Med
January 2025
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Orthopaedic Institute for Children, Los Angeles, California, USA; Boulder Medical Center, Boulder, Colorado, USA.
Background: Peripheral nerve blocks (PNBs) are frequently utilized as a regional anesthetic in pediatric orthopaedic surgery for postoperative pain control and reduced time to discharge; however, short- and long-term complications after these procedures are variably reported.
Purpose: To identify the frequency of long-term complications in pediatric patients who received regional anesthesia for a lower extremity orthopaedic procedure.
Study Design: Systematic review; Level of evidence, 4.
Culprit allergen prevalence in polyreactive individuals reflects prescription trends: A tool for estimating comparative anaphylaxis risk using the example of neuromuscular blocking agents.
Anaesth Intensive Care
January 2025
Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Australia.
Prescription-event monitoring (PEM) is the current gold standard for determining the risk of rare drug side-effects and comparing the risk between agents; however, spontaneous or prompted reporting schemes have low case-detection rates and exposure may be difficult to estimate. A novel method is described that allows a comparative adverse event rate between two drugs to be estimated-based on patterns of cross-reactivity-requiring only a sample of cases and no direct knowledge of drug exposure rates. Agreement was compared between the novel method and historical estimates of risk using PEM for comparative risk of rocuronium versus vecuronium anaphylaxis.
View Article and Find Full Text PDFThe effect of dexmedetomidine vs. atracurium on intubation condition in children - a randomized clinical trial.
BMC Res Notes
January 2025
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Using neuromuscular blocking agents (NMBA) in pediatric induction protocol is a challenging matter. Therefore, in this study, we aimed to find a safer way for anesthesia in children. We compared the effects of dexmedetomidine with atracurium on intubation conditions in children aged 6-12 years under general anesthesia.
View Article and Find Full Text PDFImpact of Liver Disease on Use of Muscle Relaxants in Anesthesia: A Comprehensive Review.
Med Sci Monit
January 2025
Department of Nephrology, Transplantology and Internal Diseases, Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
Article Synopsis
- Skeletal muscle relaxants are commonly used in anesthesia for surgeries, mechanical ventilation, and intubation, creating a conduction block at the neuromuscular junction.
- Reversal agents, like neostigmine and sugammadex, help terminate the neuromuscular blockade and prevent residual effects, but their efficacy can be affected by liver and kidney dysfunction.
- Liver damage, which can stem from various causes including drug toxicity and metabolic disorders, impairs drug metabolism and can lead to systemic complications, ultimately impacting the use of muscle relaxants in patients with liver disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!