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Interferons and Cytokines Induce Transcriptional Activation of the Long-Interspersed Element-1 in Myeloid Cells from Autoimmune Patients.
Eur J Immunol
March 2025
Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Approximately 17% of our genome consists of copies of the retrotransposon "long interspersed element-1" (LINE-1 or L1). Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the L1-encoded ORF1 protein (ORF1p), which correlate with disease activity and interferon gene signature. ORF1p is present in neutrophils from patients with active disease in perinuclear ribonucleoprotein particles that also contain Ro60 and nucleic acid sensors.
View Article and Find Full Text PDFGenome-wide identification of F-box-LRR gene family and the functional analysis of CsFBXL13 transcription factor in tea plants.
Funct Integr Genomics
March 2025
Department of Tea College of Horticulture, Hunan Agricultural University, Changsha, 410128, China.
This study focused on the identification and functional analysis of the F-box-LRR (FBXL) protein family in tea tree (Camellia sinensis), aiming to reveal its role in spring bud germination and environmental adaptation. Thirty-seven members of the tea tree F-box-LRR gene family were identified and systematically analyzed for their chromosomal localization, gene structure, conserved motifs, and cis-acting elements by bioinformatics methods. It was found that these genes were distributed on 14 chromosomes, with strong conserved and inter-gene covariance characteristics.
View Article and Find Full Text PDFAstrocyte alterations during Osmotic Demyelination Syndrome: intermediate filaments, aggresomes, proteasomes, and glycogen storages.
Ultrastruct Pathol
March 2025
Department of Medicine, Laboratory of Neurodegeneration and Regeneration URPHyM, NARILIS, University of Namur, Namur, Belgium.
Introduction: A murine model mimicking the human osmotic demyelination syndrome (ODS) revealed with histology demyelinated alterations in the relay posterolateral (VPL) and ventral posteromedial (VPM) thalamic nuclei 12 h and 48 h after chronic hyponatremia due to a fast reinstatement of osmolality. Abnormal expression astrocyte markers ALDHL1 and GFAP with immunohistochemistry in these ODS altered zones, prompted aims to verify in both protoplasmic and fibrillar astrocytes with ultrastructure those changes and other associated subcellular modifications.
Method: This ODS investigation included four groups of mice: Sham (NN; = 13), hyponatremic (HN; = 11), those sacrificed 12 h after a fast restoration of normal natremia (ODS12h; = 6), and mice sacrificed 48 h afterward, or ODS48 h ( = 9).
Genome-wide identification and expression profile analysis of TALE superfamily genes under hormone and abiotic stress in maize ( L.).
Front Plant Sci
February 2025
Department of Food Testing, Binzhou Testing Center, Binzhou, Shandong, China.
Introduction: The three-amino-acid-loop-extension (TALE) of the homeobox superfamily genes plays important roles in plant growth, development, and responses to environmental stress. Although TALE members have been identified in various species, they have not been systematically characterized in maize and their expression profiles under ABA hormone and abiotic stress are unknown.
Methods: Bioinformatics methods were employed to identify the TALE family genes in the maize genome.
Hair follicle neural crest stem cells reside in the bulge region of the outer root sheath of hair follicles, originate from the ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineering applications. These cells mainly reside in a hypoxic microenvironment that favors the maintenance of stemness. Recently, many studies have elucidated the involvement of the Hippo pathway in the regulation of stem cell fate.
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