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Expiration-Triggered Sinus Arrhythmia Predicts Mortality Risk in the General Elderly Population.
J Cardiovasc Dev Dis
January 2025
Department Clinical Medicine, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.
Reduced respiratory sinus arrhythmia, quantified as expiration-triggered sinus arrhythmia (ETA) from simultaneous electrocardiogram and respiration recordings, is a strong long-term mortality predictor in myocardial infarction survivors. Here, we investigated whether ETA also predicts mortality risk in the general elderly population. ETA was quantified from 30-min electrocardiogram and respiration recordings in 1788 general population subjects aged ≥60 years, who were then followed for a median of 4.
View Article and Find Full Text PDFOleuropein supplementation increases resting skeletal muscle fractional PDH activity but does not influence whole-body metabolism: A randomized, double-blind, placebo-controlled trial in healthy, older males.
J Nutr
February 2025
NUTRIM, Institute of Nutrition and Translational Research In Metabolism, Department of Human Biology, Maastricht University Medical Centre+. Electronic address:
Background: The polyphenol oleuropein activates mitochondrial calcium import, which increases pyruvate dehydrogenase (PDH) activity. Preclinically, this increase in PDH activity following oleuropein supplementation resulted in improved mitochondrial bioenergetics and fatigue resistance.
Objective: This study aimed to examine the effects of acute and chronic oleuropein supplementation on muscle energy metabolism, whole-body substrate metabolism, strength, and fatigue resistance in older males.
Critical parameters on Zika virus-like particles' generation.
J Virol Methods
May 2025
Laboratório de Engenharia de Bioprocessos. Escola de Artes, Ciências e Humanidades (EACH), Universidade de São Paulo, Rua Arlindo Béttio, 1000, São Paulo, SP CEP 03828-000, Brazil. Electronic address:
The Zika virus became a global threat in 2015 due to its association with microcephaly. Preventing its spread depends on developing vaccines, with virus-like particles (VLP) being a promising approach, especially because of their safety profile and high immunogenicity. This study focused on the production of Zika VLP using Sf9 cells and the baculovirus expression system, evaluating cell growth kinetics, nutrient consumption, and metabolite production in Sf-900™ III medium.
View Article and Find Full Text PDFCETP expression in females increases body metabolism under both cold exposure and thermoneutrality contributing to a leaner phenotype.
FASEB J
February 2025
Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, Brazil.
Susceptibility to obesity differs depending on the genetic background and housing temperatures. We have recently reported that CETP expressing female mice are leaner due to increased lipolysis, brown adipose tissue (BAT) activity, and body energy expenditure compared to nontransgenic (NTg) littermates under standard housing temperature (22°C). The aim of this study is to evaluate how CETP expression affects body temperature, composition, and metabolism during cold exposure (4°C) and thermoneutrality (30°C).
View Article and Find Full Text PDFEfficacy of double filtration plasmapheresis in hyperlipidemia acute pancreatitis: a retrospective observational study.
Lipids Health Dis
January 2025
Department of Gastroenterology, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, 650051, China.
Background: This study examines the role and effectiveness of double filtration plasmapheresis (DFPP) in managing hyperlipidemiclipidemic acute pancreatitis (HLAP).
Methods: Comparative analysis was conducted between two groups: one treated with DFPP and one without. Comparative parameters included blood lipid levels, inflammatory factors, vital signs, disease severity scores, and complication rates.
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