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Enhancement of aerobic sludge granulation by quorum sensing signaling molecules mediated by biomimetic bacterial extracellular vesicles.
J Environ Manage
January 2025
Department of Environmental Engineering, College of Ecology and Environment, Nanjing Forestry University, Nanjing, 210037, China. Electronic address:
The addition of exogenous quorum sensing signaling molecules to the activated sludge system enables rapid sludge granulation. However, signaling molecules exposed to the environment are easily degraded, and their quorum sensing effects cannot be maintained in the long term. Therefore, they must be frequently added, which leads to an increase in operational costs.
View Article and Find Full Text PDFFerrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation.
J Orthop Surg Res
January 2025
Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150001, Heilongjiang Province, China.
Background: Osteoporosis (OP) is a systemic disease characterized by low bone mass. New progress has been made in the study of OP, such as lipid peroxidation. However, the role of lipid peroxides in osteoclast differentiation is still unclear.
View Article and Find Full Text PDFA Novel Endophytic Fungus R-423 for the Control of Root Rot in Pigeon Pea as Reflected by the Alleviation of Reactive Oxygen Species-Mediated Host Defense Responses.
J Agric Food Chem
January 2025
College of Forestry, Beijing Forestry University, Beijing 100083, People's Republic of China.
root rot is a devastating fungal disease that causes significant yield losses in legume crops. A novel endophytic fungus R-423 isolated from pigeon pea had a significant antagonistic capacity against . R-423 extracts could inhibit growth and cause it to die.
View Article and Find Full Text PDFAbsolute membrane protein abundance of P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins in term human placenta tissue and commonly used cell systems: Application in physiologically based pharmacokinetic modeling of placental drug disposition.
Drug Metab Dispos
January 2025
Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom; Certara Predictive Technologies, Sheffield, United Kingdom.
The placenta acts as a barrier, excluding noxious substances while actively transferring nutrients to the fetus, mediated by various transporters. This study quantified the expression of key placental transporters in term human placenta (n = 5) and BeWo, BeWo b30, and JEG-3 placenta cell lines. Combining these results with pregnancy physiologically based pharmacokinetic (PBPK) modeling, we demonstrate the utility of proteomic analysis for predicting placental drug disposition and fetal exposure.
View Article and Find Full Text PDFCancer-associated fibroblasts promote oral squamous cell carcinoma progression by targeting ATP7A via exosome-mediated paracrine miR-148b-3p.
Cell Signal
January 2025
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, 56 Lingyuan Road West, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Cuproptosis is a newly discovered form of non-apoptotic cell death. Cancer-associated fibroblasts (CAFs) can secrete various bioactive substances, including exosomes, to promote tumor progression. However, the impact of CAFs on the regulation of copper metabolism and cuproptosis in oral squamous cell carcinomas (OSCC) has not been investigated.
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