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Unlocking the Potential: Phytoestrogens and Cardiovascular Health.
Curr Cardiol Rev
January 2025
Department of Internal Medicine, Penn State Milton S. Hershey Medical Center, PA, USA Korea.
Phytoestrogens are plant-derived compounds resembling human estrogen and have recently gained attention due to their potential role in improving cardiovascular health. These compounds exert their effects through various mechanisms, including interactions with estrogen receptors, growth factor receptors, inflammatory mediators, thrombogenic reactions, and apoptotic pathways. This results in cardioprotective effects like modulating endothelial function, decreasing vessel tone, reducing inflammation, altering lipid profiles, and influencing arrhythmogenesis.
View Article and Find Full Text PDFEvaluation of the interface of metallic-coated biodegradable polymeric stents with prokaryotic and eukaryotic cells.
Bioact Mater
April 2025
University of Coimbra, CEMMPRE, Department of Mechanical Engineering, 3030-788, Coimbra, Portugal.
Polymeric coronary stents, like the ABSORB™, are commonly used to treat atherosclerosis due to their bioresorbable and cell-compatible polymer structure. However, they face challenges such as high strut thickness, high elastic recoil, and lack of radiopacity. This study aims to address these limitations by modifying degradable stents produced by additive manufacturing with poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) with degradable metallic coatings, specifically zinc (Zn) and magnesium (Mg), deposited via radiofrequency (rf) magnetron sputtering.
View Article and Find Full Text PDFIncreasing provider awareness of Lp(a) testing for patients at risk for cardiovascular disease: A comparative study.
Am J Prev Cardiol
March 2025
St. Elizabeth Healthcare, 20 Medical Village Drive, Suite 103, Edgewood, KY 41017, USA.
Background: Lipoprotein(a) [Lp(a)] is a low-density lipoprotein variant with atherogenic, thrombogenic, and pro-inflammatory properties that may have numerous pathologic effects, including dyslipidemia. Screening for Lp(a) is clinically significant, due to its causal role in atherosclerotic cardiovascular disease (ASCVD). Among clinicians, however, there remains a general lack of both clinical awareness of Lp(a) and adequate tools to track Lp(a) testing in patients.
View Article and Find Full Text PDFEstrogen, progestin, and beyond: thrombotic risk and contraceptive choices.
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Hormonal contraceptive therapy (estrogens and/or progestogens) includes different formulations associated with varying venous thromboembolism (VTE) risks. The thrombogenicity of combined hormonal contraceptives (CHCs) is due at least in part to multiple changes in clotting factors and the vasculature and is dependent on both estrogen dose and type of progestin. Transdermal patch and vaginal ring users have similar or higher VTE risk as combined oral contraceptive users.
View Article and Find Full Text PDFFabrication of nanoparticle-reinforced composite hydrogel for improved durability, antifouling, and thrombosis-resistance in arteriovenous grafts.
Colloids Surf B Biointerfaces
November 2024
School of Nano-Tech and Nano-Bionics, University of Science and Technology of China (USTC), Hefei 230026, PR China; CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou 215123, PR China. Electronic address:
Article Synopsis
- Arteriovenous grafts, used in hemodialysis, often face serious issues like thrombosis and infections that hinder their effectiveness.
- Researchers created a surface-modified nanohybrid hydrogel by combining clay nanoparticles coated with zwitterionic sulfobetaine methacrylate onto a sodium alginate/polyvinyl alcohol base.
- This new hydrogel demonstrated improved mechanical strength, biocompatibility, and antifouling properties, making it a promising option for use in blood-contacting implants.
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