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From spermatogenesis to fertilisation: the role of melatonin on ram spermatozoa.
Domest Anim Endocrinol
January 2025
BIOFITER-IUCA, Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet 177, 50013 Zaragoza, Spain. Electronic address:
This review presents recent findings on the effect of melatonin on ram spermatozoa. This hormone regulates seasonal reproduction in the ovine species through the hypothalamic-pituitary-gonadal axis, but it also exerts direct effects on spermatogenesis, seminal quality and fertility. In the testis, melatonin stimulates blood flow to this organ, but it also appears to be involved in the differentiation of spermatogonial stem cells and the secretion of testosterone through the MT1 and MT2 receptors.
View Article and Find Full Text PDFExploring potential drug targets for SLE through Mendelian randomization and network pharmacology.
PLoS One
January 2025
Department of Laboratory, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, P.R. China.
Background: Systemic lupus erythematosus (SLE) is a complex and incurable autoimmune disease, so several drug remission for SLE symptoms have been developed and used at present. However, treatment varies by patient and disease activity, and existing medications for SLE were far from satisfactory. Novel drug targets to be found for SLE therapy are still needed.
View Article and Find Full Text PDFA Review on the Applications of Quantum Dots in Sample Preparation.
J Sep Sci
January 2025
Department of Ocean Science, Iranian National Institute for Oceanography and Atmospheric Science, Tehran, Iran.
In recent years, despite significant advances in preconcentration and preparation techniques that have led to efficient recovery and accurate measurement of target compounds. There is still a need to develop adsorbents with unique and efficient features such as high pore volume and surface area, reactivity, easy synthesis, low toxicity, and compatibility with the environment, which increase the adsorption capacity and increase extraction efficiency. Semiconductor nanocrystals called quantum dots (QDs) with a size of less than 10 nm are three-dimensional nanoparticles with a spherical, rod, or disc structure that have significant potential in extraction as adsorbents due to their excellent properties such as low toxicity, reactivity, environmental friendliness, and hydrophilic and hydrophobic interactions.
View Article and Find Full Text PDFABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis.
JACC Basic Transl Sci
December 2024
Division of Cardiology, Departments of Internal Medicine Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary artery disease severity. Mechanistically, ABCA1-seRNA upregulated cholesterol efflux by interacting with mediator complex subunit 23 and recruiting retinoid X receptor-alpha and liver X receptor-alpha to promote ABCA1 transcription in a manner.
View Article and Find Full Text PDFCalcium phosphate formation and deposition in ischemic neurons.
PLoS One
January 2025
Biomedical Engineering Department, Northwestern University, Evanston, IL, United States of America.
Ischemic stroke causes acute brain calcium phosphate (CaP) deposition, a process involving primarily the injured neurons. Whereas the adverse impact of CaP deposition on the brain structure and function has been recognized, the underlying mechanisms remain poorly understood. This investigation demonstrated that the neuron-expressed, plasma membrane-associated Ca2+-binding proteins annexin (Anx) A2, AnxA5, AnxA6, and AnxA7 contributed to neuronal CaP deposition in the mouse model of ischemic stroke.
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