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Objetives: Patients with digitalis intoxication (DI) and hyperkalaemia are frequently encountered in the emergency department (ED). This alteration may require intravenous (iv) calcium, but its administration has been considered to increase cardiotoxicity and mortality in patients with DI. We studied the effect of iv calcium on mortality and 30-day readmission in patients with hyperkalaemia and DI.

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[European Society of Cardiology (ESC) guidelines on atrial fibrillation 2024 : What is new and what is important?].

Herz

November 2024

Klinik für Kardiologie, Angiologie, Intensivmedizin, Deutsches Herzzentrum der Charité, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Deutschland.

Article Synopsis
  • * New recommendations include performing transthoracic echocardiography for newly diagnosed AF patients and suggesting SGLT2 inhibitors for heart failure management regardless of left ventricular ejection fraction.
  • * The CHA2DS2-VA score now simplifies thromboembolism risk assessment, while pulmonary vein isolation is recommended as a first-line treatment for paroxysmal AF, emphasizing the need for ongoing risk factor evaluation and treatment of related health issues.
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Article Synopsis
  • - Nonparoxysmal junctional tachycardia with Wenckebach exit block is usually linked to digitalis toxicity.
  • - This report highlights a case where the arrhythmia appeared without the use of digitalis medication.
  • - The patient in this case had underlying structural heart disease, suggesting that other factors may trigger this type of arrhythmia.
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Article Synopsis
  • Bidirectional ventricular tachycardia (BVT) is a rare and serious heart rhythm issue marked by changes in the QRS axis with each heartbeat, often linked to digitalis toxicity.
  • A 62-year-old woman who had heart surgery developed BVT after being treated with digoxin and diuretics, leading to concerns about the interaction between these medications.
  • The case stresses the need for careful monitoring of digoxin levels in patients on diuretics and suggests supportive treatments if BVT occurs, like stopping digoxin and providing potassium and magnesium supplements.
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"Cardiac glycosides"-quo vaditis?-past, present, and future?

Naunyn Schmiedebergs Arch Pharmacol

December 2024

Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Straße 9, 97078, Würzburg, Germany.

Article Synopsis
  • Digitalis glycosides, or cardiac glycosides, are drugs that inhibit the Na/K-ATPase and are commonly used to treat heart failure and atrial fibrillation.
  • Despite their effectiveness, these drugs have a narrow therapeutic range, leading to debates about their necessity and safety in these conditions.
  • The article aims to review the historical context, key research findings, and the overlooked advantages and disadvantages of using digitalis glycosides in clinical practice.
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