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Focus on brown dog tick-transmitted Rocky Mountain spotted fever in dogs and people: shared threats and solutions.
J Am Vet Med Assoc
January 2025
3Red de Biología y Conservación de Vertebrados, Instituto de Ecología AC, Veracruz, México.
Rocky Mountain spotted fever (RMSF) kills people and dogs in rural communities throughout the Americas and in urban epidemics in Brazil and Mexico. The companion Currents in One Health by Foley et al, AJVR , March 2025, addresses the urban ecology of this devastating disease across the Americas. Cases acquired from Dermacentor spp ticks are sylvatic and sporadic, in contrast with peridomestic cases from Rhipicephalus sanguineus sensu lato, which relies on dogs as hosts.
View Article and Find Full Text PDFContribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis.
BMC Pediatr
January 2025
Department of Pediatrics, Center of Pediatric Nephrology and Transplantation (CPNT), Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Background: Anemia is prevalent among pediatric patients diagnosed with end-stage kidney disease (ESKD). In addition, erythropoiesis-stimulating agents (ESA) and iron supplementation are considered the cornerstones in the management of anemia. However, a significant proportion of patients remain anemic.
View Article and Find Full Text PDFA machine learning model accurately identifies glycogen storage disease Ia patients based on plasma acylcarnitine profiles.
Orphanet J Rare Dis
January 2025
Laboratory of Metabolic Diseases, Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Postbus, Groningen, 30001 - 9700 RB, the Netherlands.
Background: Glycogen storage disease (GSD) Ia is an ultra-rare inherited disorder of carbohydrate metabolism. Patients often present in the first months of life with fasting hypoketotic hypoglycemia and hepatomegaly. The diagnosis of GSD Ia relies on a combination of different biomarkers, mostly routine clinical chemical markers and subsequent genetic confirmation.
View Article and Find Full Text PDFIntegrating lipid metabolomics, serum medicinal chemistry, network pharmacology and experimental validation to explore the mechanism of Sanmiao wan in the treatment of rheumatoid arthritis.
J Ethnopharmacol
January 2025
Mudanjiang Normal University, Mudanjiang, 157011, China.
Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a common autoimmune disease with a high clinical morbidity and leads to persistent chronic inflammation. Sanmiao wan is a classic formula for the treatment of RA, and the results of clinical and experimental studies have shown its therapeutic effect on RA. However, its mechanism of action remains unclear.
View Article and Find Full Text PDFThe association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis.
BMC Musculoskelet Disord
October 2024
Internal Medicine Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Article Synopsis
- Knee osteoarthritis (KOA) is a major global disability issue, and the study aimed to explore the link between the ADAMTS14 gene polymorphism and KOA, along with associated risk factors.
- A case-control study involving 158 KOA patients and 120 matched controls showed a significant difference in ADAMTS14 gene rs4747096 allele frequencies, with certain genotypes (AA and AG) linked to increased KOA risk.
- Key risk factors identified include age over 50, obesity, prolonged standing at work, and the recessive inheritance pattern of the A allele, indicating a need for further research on the genetic influence on KOA development.
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