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ELISA with recombinant antigen Lb6H validated for the diagnosis of American tegumentary leishmaniasis.
PLoS One
June 2024
Faculdade de Medicina, Instituto de Medicina Tropical de Sao Paulo, Laboratório de Soroepidemiologia, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil.
American tegumentary leishmaniasis (ATL) diagnosis is an open question, and the search for a solution is urgent. The available tests that detect the etiological agent of the infection are specific for ATL diagnosis. However, they present disadvantages, such as low sensitivity and the need for invasive procedures to obtain the samples.
View Article and Find Full Text PDFChagas Disease and Leishmaniasis, Sympatric Zoonoses Present in Human from Rural Communities of Venezuela.
Acta Parasitol
March 2024
Instituto de Zoología y Ecología Tropical (IZET), Facultad de Ciencias, Universidad Central de Venezuela (UCV), Caracas, Venezuela.
Purpose: Trypanosoma cruzi and Leishmania spp. coexist in several endemic areas, and there are few studies of Chagas disease and leishmaniasis coinfection worldwide; for this reason, the objective of this work was to determine the Chagas disease and leishmaniasis coinfection in several rural communities co-endemic for these diseases.
Methods: A total of 1107 human samples from six co-endemic rural communities of Cojedes state, Venezuela, were analyzed.
Incidence of Human and Free-Ranging Wild Rodent Infections with () , Aetiological Agent of Cutaneous Leishmaniasis.
Pathogens
November 2023
Departament of Immunology, Instituto Aggeu Magalhães/FIOCRUZ, Cidade Universitária, Recife 50740-465, PE, Brazil.
Article Synopsis
- The study assessed human and wild rodent infection rates of leishmaniasis in northeast Brazil to understand how transmission occurs in altered environments.
- Human participants showed significant rates of leishmanin skin test positivity (34.3%-56.3%) and scars indicative of ACL (12.2%-47.5%), with infection probability linked to age and exposure duration.
- Rodents exhibited high rates of asymptomatic infection and were likely contributing to ongoing human transmission, highlighting the connection between rodents, human habitats, and potential leishmaniasis spread.
A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection.
PLoS Negl Trop Dis
December 2023
Laboratory of Medical Parasitology, Biotechnology and Biomolecular, Pasteur Institute of Tunis, Tunis, Tunisia.
Background: This study aimed to define immunological markers of exposure to L. major parasites and identify correlates of protection against infection.
Methods: We analyzed a cohort of 790 individuals at risk of developing ZCL living in endemic areas with varying L.
Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field.
Nat Commun
November 2023
Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
The leishmanin skin test was used for almost a century to detect exposure and immunity to Leishmania, the causative agent of leishmaniasis, a major neglected tropical disease. Due to a lack of antigen used for the intradermal injection, the leishmanin skin test is no longer available. As leishmaniasis control programs are advancing and new vaccines are entering clinical trials, it is essential to re-introduce the leishmanin skin test.
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