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Time- and anion-dependent stimulation on triphosphopyridine nucleotide followed by antioxidant responses in Vibrio fischeri after exposure to 1-ethyl-3-methylimidazolium salts.
Chemosphere
November 2016
Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
A toxicity database of over 157 ionic liquids (ILs) was established on Vibrio fischeri (VF). The database contained mainly monotonic concentration-response relationship, and its application in risk assessment was challenged by potential non-monotonic hormetic effects of ILs. In the present study, the hormetic effects of 1-ethyl-3-methylimidazolium salts ([emim]X, X = BF4, Cl and Br) were confirmed on VF, and biochemical explanations were explored in a time-dependent manner.
View Article and Find Full Text PDFProtective effect of nitric oxide on hepatopulmonary syndrome from ischemia-reperfusion injury.
World J Gastroenterol
July 2012
Department of Hepatobiliary Surgery and Liver Transplant Center, Jinan Military Region, The Chinese PLA 401st Hospital, Qingdao 266071, Shandong Province, China.
Aim: To evaluate immunological protection of nitric oxide (NO) in hepatopulmonary syndrome and probable mechanisms of ischemia-reperfusion (IR) injury in rat liver transplantation.
Methods: Sixty-six healthy male Wistar rats were randomly divided into three groups (11 donor/recipient pairs). In group II, organ preservation solution was lactated Ringer's solution with heparin 10, 000/μL at 4 °C.
Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats.
Eur J Cancer Prev
August 2007
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
This is an extensive study in a defined initiation-promotion hepatocellular carcinoma model of hepatocarcinogenesis (in rats) in which many important marker enzymes and isoenzymes and 8-hydroxydeoxyguanosine formation have been studied together with two very important cellular proliferating genes, insulin-like growth factor II and c-raf.1, known for their role in hepatocellular cancer development. Experiments were carried out on hepatic tissues of male Sprague-Dawley rats.
View Article and Find Full Text PDFBiochemical basis of selenomethionine-mediated inhibition during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Eur J Cancer Prev
December 1996
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Supplementation of selenium in the form of selenomethionine (8 ppm) in drinking water daily has been found to be highly effective in reducing cancer incidence in male Sprague-Dawley rats fed 2-acetylaminofluorine (2-AAF) (0.05%) in the basal diet daily for 16 weeks. Selenomethionine treatment before initiation, during initiation or during the selection/promotion phases of hepatocarcinogenesis has been found to be effective in elevating hepatic microsomal cytochrome b5, cytochrome P-450 contents, triphosphopyridine nucleotide-cytochrome c-reductase and cytosolic aryl hydrocarbon hydroxylase activities to a statistically significant level measured either in the hyperplastic nodules or in the non-nodular surrounding liver parenchyma compared with 2-AAF control rats.
View Article and Find Full Text PDFSonicates from unstimulated human neutrophils produce no measurable superoxide since the superoxide-generating enzyme, NADPH oxidase, is inactive in these preparations. Previous attempts to activate the oxidase in disrupted cells with conventional neutrophil stimuli have been unsuccessful. This report describes a cell-free system in which arachidonic acid (82 microM) was able to activate superoxide generation that was dependent upon the presence of NADPH and the sonicate.
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