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Nucleic acid recognition during prokaryotic immunity.
Mol Cell
January 2025
Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address:
Parasitic elements often spread to hosts through the delivery of their nucleic acids to the recipient. This is particularly true for the primary parasites of bacteria, bacteriophages (phages) and plasmids. Although bacterial immune systems can sense a diverse set of infection signals, such as a protein unique to the invader or the disruption of natural host processes, phage and plasmid nucleic acids represent some of the most common molecules that are recognized as foreign to initiate defense.
View Article and Find Full Text PDFRecovery of Complex Isolates Including Pre-Extensively Drug-Resistant Strains From Cattle at a Slaughterhouse in Chennai, India.
Open Forum Infect Dis
January 2025
Department of Immunology, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Background: India has the highest global burden of human tuberculosis (TB) and the largest cattle herd with endemic bovine TB (bTB). However, the extent of cross-species transmission and the zoonotic spillover risk, including drug-resistant complex (MTBC) strains circulating in cattle, remain uncharacterized.
Methods: To address this major knowledge gap, we investigated tissue samples from 500 apparently healthy cattle at a slaughterhouse in Chennai, India.
Adaptation of clinical bacteriology techniques for remote polar research.
Appl Environ Microbiol
January 2025
Clinical Infection Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.
Unlabelled: Remote polar regions offer unique opportunities and significant challenges for antimicrobial resistance research in a near-pristine environment. While core microbiology techniques continue to have an important role in supporting environmental research, the severe cold climate presents considerable challenges to laboratory research. We explore adaptations required for core bacteriology investigations in polar regions on an unsupported remote expedition c.
View Article and Find Full Text PDFUncovering the substrate of olefin synthase loading domains in cyanobacteria sp. strain PCC 7002.
RSC Chem Biol
January 2025
Department of Chemical and Biological Engineering, University of Wisconsin - Madison Madison Wisconsin 53706 USA
Cyanobacteria are widespread, photosynthetic, gram-negative bacteria that generate numerous bioactive secondary metabolites complex biosynthetic enzymatic machinery. The model cyanobacterium sp. strain PCC 7002, hereafter referred to as PCC 7002, contains a type I polyketide synthase (PKS), termed olefin synthase (OlsWT), that synthesizes 1-nonadecene and 1,14-nonadecadiene: α-olefins that are important for growth at low temperatures.
View Article and Find Full Text PDFRheumatic Heart Disease Burden in Africa and the Need to Build Robust Infrastructure.
JACC Adv
December 2024
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Rheumatic heart disease (RHD) is an important public health problem in Africa. Mapping the epidemiology of RHD involves elucidating its geographic distribution, temporal trends, and demographic characteristics. The prevalence of RHD in Africa varies widely, with estimates ranging from 2.
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