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Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.
Pest Manag Sci
January 2025
Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA.
Background: Bed bugs are blood-feeders that rapidly proliferate into large indoor infestations. Their bites can cause allergies, secondary infections and psychological stress, among other problems. Although several tactics for their management have been used, bed bugs continue to spread worldwide wherever humans reside.
View Article and Find Full Text PDFComposition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery.
Nat Commun
January 2025
Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Recalcitrant bacterial infections can be caused by various types of dormant bacteria, including persisters and viable but nonculturable (VBNC) cells. Despite their clinical importance, we know fairly little about bacterial dormancy development and recovery. Previously, we established a correlation between protein aggregation and dormancy in Escherichia coli.
View Article and Find Full Text PDFAn acid polysaccharide from Mentha haplocalyx exerts the antifatigue effect via activating AMPK.
Int J Biol Macromol
January 2025
Department of Chinese Osteo-traumatology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China. Electronic address:
Fatigue is a pathological state that can impair physical and cognitive performance, making the development of effective therapeutic strategies crucial. In this study, an acid polysaccharide (MHa) was isolated from Mentha haplocalyx. Structural analysis showed that MHa (40.
View Article and Find Full Text PDFNew 2-indolinone-indole hybrid compounds carrying a benzoyl moiety as tyrosine kinase inhibitors.
Bioorg Chem
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University 34116 Istanbul, Turkey.
In this study, new 2-indolinone-indole hybrid compounds (4a-s) carrying a benzoyl moiety were synthesized and their cytotoxic effects were examined against pancreatic (MIA-PaCa-2) and colon (HT-29 and HCT-116) cancer cells by MTT assays. Most of the tested compounds exhibited a better inhibitory activity and safety profile than the reference standard sunitinib malate against MIA-PaCa-2 and HCT-116 cancer cells. Compound 4e displayed the greatest cytotoxic effect on HCT-116 cell with an IC value of 0.
View Article and Find Full Text PDF24-Epibrassinolide treatment alleviates frost damage of apple flower via regulating proline, ROS, and energy metabolism.
Plant Physiol Biochem
January 2025
Shandong Institute of Pomology, Shandong Academy of Agricultural Sciences, Taian, 271000, China. Electronic address:
Frost damage to apple flowers significantly affects both the quality and yield of apples, potentially leading to substantial economic losses. This study investigates the application of the environmentally friendly plant hormone 24-epibrassinolide (EBR) on apple flowers to assess its effects under frost stress conditions. The findings indicate that exogenous EBR treatment maintained favorable flower morphology, mitigated pistil browning, and reduced ion leakage.
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