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Dynamic changes of heterogeneous cell wall macromolecules in differentiating conifer xylem using cytochemical localization.
Int J Biol Macromol
January 2025
Department of Wood Anatomy and Utilization, Research Institute of Wood Industry, Chinese Academy of Forestry, Beijing 100091, China; Wood Specimen Resource Center (WOODPEDIA) of National Forestry and Grassland Administration, Beijing 100091, China. Electronic address:
Article Synopsis
- Understanding the changes in cell wall components during xylem differentiation is crucial for grasping the structure of wood, especially at the secondary cell wall layer level.
- In the study of Pinus bungeana, it was found that crystalline cellulose and glucomannan were deposited before xylan and lignin, with lignification starting in the primary cell wall corners as the S layer developed.
- Immunofluorescence results showed that glucomannan was deposited earlier than xylan, and while pectins were concentrated in the primary walls, they decreased as tracheid walls differentiated, with ray cells lagging behind axial tracheids in their development.
Fibronectin binds integrin α5β1 to regulate macular neovascularization through the Wnt/β-catenin signaling pathway.
Exp Eye Res
May 2024
Department of Ophthalmology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China. Electronic address:
Article Synopsis
- Age-related macular degeneration (AMD) is a leading cause of vision loss among older adults, primarily due to macular neovascularization (MNV) and subretinal fibrosis, which are linked to changes in extracellular matrix protein composition.
- The study investigates the role of fibronectin (FN) and its receptor, integrin α5β1, in promoting MNV, using mouse models and a cell line to analyze FN expression and its molecular mechanisms through various assays.
- Results showed increased FN and α5β1 levels in models of MNV, and silencing FN led to reduced cell migration and blood vessel formation, indicating FN's significant role in the development of AMD and its potential targeting for treatment.
A comprehensive stem cell laboratory module with blended learning for medical students at Tongji University.
Biochem Mol Biol Educ
May 2024
Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai, China.
The laboratory practice "Primary culture and directional differentiation of rat bone marrow mesenchymal stem cells (BMSCs)" is part of a required course for sophomore medical students at Tongji university, which has been conducted since 2012. Blended learning has been widely applied in medical courses. Based on a student-centered teaching philosophy, we reconstructed a comprehensive stem cell laboratory module with blended learning in 2021, aiming to facilitate students in enhancing their understanding of the multi-lineage differentiation potential of stem cells and improve their experimental skills, self-directed learning ability, and innovative thinking.
View Article and Find Full Text PDF[Apelin-13 promotes mitochondrial autophagy and improves rat myocardial ischemia-reperfusion injury by blocking PINK1/parkin signaling pathway].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
November 2023
Department of Geriatrics, Second Affiliated Hospital of Hainan Medical College, Haikou 570311, China. *Corresponding author, E-mail:
Objective To investigate the effect of adipocytokine Apelin-13 (AP13) on mitochondrial autophagy in myocardial ischemia reperfusion injury (MIRI) and its mechanism. Methods MIRI model was established by ligating the coronary artery branches of rats. The rats are divided into sham group, AP13-treated sham group, MIRI group and AP13-treated MIRI group.
View Article and Find Full Text PDF[Differentiated embryonic chondrocyte gene 2 (DEC2) inhibits transdifferentiation of mouse glomerular endothelial cells and renal fibrosis by blocking TGF-β/ROCK1 signaling pathway].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2023
Department of Immunology and Pathology, Shandong College of Traditional Chinese Medicine, Yantai 264199, China.
Objective To explore the protective mechanism of transdifferentiation of glomerular endothelial cells based on the differentiated embryonic chondrocyte gene 2 (DEC2) via the TGF-β/ROCK1 signaling pathway. Methods The 24 mice were randomly divided into sham group, UUO group, UUO combined with vector group and UUO combined with DEC2 group, with 6 mice in each group. A unilateral ureteral obstruction (UUO) model was established in each group, except for the sham group.
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