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Long-term pharmacological torpor of rats with feedback-controlled drug administration.
Life Sci Space Res (Amst)
February 2021
Russian Foundation for Advanced Research, Russia.
The maintenance of pharmacological torpor and hypothermia (body temperature 28 °C - 33 °C) in rats for a week is presented. For this purpose, our laboratory has developed a device (BioFeedback-2) for the feed-back controlled multiple injections of small doses of a pharmacological composition that we created earlier. On the 7th day, the rat spontaneously come out of the pharmacological torpor, the body temperature returned to normal, and on the 8th day, the animal could consume food and water.
View Article and Find Full Text PDF[Antioxidant status in patients with paranoid schizophrenia and Alzheimer disease].
Zh Nevrol Psikhiatr Im S S Korsakova
July 2020
Research Centre of Medical Genetics, Moscow, Russia.
Objective: To study the antioxidant profile of blood plasma in patients with paranoid schizophrenia and Alzheimer disease (AD).
Material And Methods: Thirty-three patients with paranoid schizophrenia and 18 patients with AD were included in the study. Patients with schizophrenia were stratified into two subgroups by response to therapy.
A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats.
Life Sci
February 2019
Russian Foundation for Advanced Research, Russia.
Aims: To initiate a state of artificial torpor we suggested a pharmacological multi-targeting strategy for simulation of the physiological pattern of natural hibernation including a significant reduction in heart rate, respiratory rate, body temperature and oxygen consumption as well as a decline in brain activity known as torpor.
Materials And Methods: We have developed a composition which initiates a pharmacologically induced torpor-like state (PITS-composition), made up of eight therapeutic agents, inert gas xenon and lipid emulsion served as a drug vehicle.
Key Findings: After a single intravenous injection to rats, PITS-composition causes a rapid decline in heart rate followed by a steady decrease in body temperature from about 38.
[POISONING BY PSYCHOPHARMACOLOGICAL DRUGS IN AZERBAIJAN: THE RESULTS OF 8-YEAR PROSPECTIVE OBSERVATION].
Georgian Med News
November 2017
Azerbaijan Medical University, Baku, Azerbaijan.
Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016.
View Article and Find Full Text PDFIncompatibility between propericiazine oral solution and tea-based drink.
Chem Pharm Bull (Tokyo)
February 2013
Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Fukuoka 814-0180, Japan.
Here, we studied the incompatibility between an oral solution of propericiazine (PCZ), an antipsychotic drug, and various commercially available bottled tea-based drinks. When 0.5 mL of the PCZ oral solution (10 mg/mL) was mixed with 16.
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