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Morphometric and histochemical characteristics of the cribriform type of intraductal carcinoma of the mammary gland.
Wiad Lek
August 2019
Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
Objective: Introduction: Due to the increasing morbidity and mortality rates from breast cancer, the problem of early, especially morphological diagnosis, continues to be important. The aim of this study to investigate the karyometric and histochemical features of cribriform pattern of parenchyma of intraductal carcinoma of the mammary gland.
Patients And Methods: Materials and methods: Operational and biopsy material was studied in form of serial sections of micropreparations of cribriform type intraductal carcinoma of the mammary gland.
Automated detection of cancer cells in effusion specimens by DNA karyometry.
Cancer Cytopathol
February 2019
Institute of Pathology, Koblenz, Germany.
Background: The average sensitivity of conventional cytology for the identification of cancer cells in effusion specimens is only approximately 58%. DNA image cytometry (DNA-ICM), which exploits the DNA content of morphologically suspicious nuclei measured on digital images, has a sensitivity of up to 91% for the detection of cancer cells. However, when performed manually, to our knowledge to date, an expert needs approximately 60 minutes for the analysis of a single slide.
View Article and Find Full Text PDFMorphologic variations in the pineal gland of the albino rat after a chronic alcoholisation process.
Tissue Cell
April 2018
Department of Human Anatomy and Embryology, University of Valencia, Valencia, Spain.
We studied the effect of alcohol on the pineal gland of 48 male Wistar rats. Animals were divided into control and experimental groups. The experimental group underwent a previous progressive alcoholisation period with ethanol diluted in water at a concentration of 40%.
View Article and Find Full Text PDF[Karyometry of BBN-induced precancerosis of the urothelium : An experimental analysis].
Urologe A
October 2016
Klinik und Poliklinik für Urologie, Hufelandstraße 55, 45147, Essen, Deutschland.
Background: The morphology of experimental precancerous lesions of the urinary bladder has been interpreted quite differently by various authors.
Objectives: The aim of this investigation was to quantify these lesions by karyometry and, thus, to gain a more reliable understanding of the process.
Materials And Methods: A total of 60 Wistar rats were fed with N‑butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at a concentration of 0.
Quantitative characterization of preneoplastic progression using single-cell computed tomography and three-dimensional karyometry.
Cytometry A
January 2011
School of Electrical, Computer, and Energy Engineering, Arizona State University, Tempe, Arizona, USA.
The development of morphological biosignatures to precisely characterize preneoplastic progression necessitates high-resolution three-dimensional (3D) cell imagery and robust image processing algorithms. We report on the quantitative characterization of nuclear structure alterations associated with preneoplastic progression in human esophageal epithelial cells using single-cell optical tomography and fully automated 3D karyometry. We stained cultured cells with hematoxylin and generated 3D images of individual cells by mathematically reconstructing 500 projection images acquired using optical absorption tomographic imaging.
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