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Abnormal alterations in structure-function coupling at the modular level in patients with postherpetic neuralgia.
Sci Rep
January 2025
Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, China.
To investigate the presence of modular loss of coupling and abnormal alterations in functional and structural networks in the brain networks of patients with postherpetic neuralgia (PHN). We collected resting-state functional magnetic resonance imaging data and diffusion tensor imaging data from 82 healthy controls (HCs) and 71 PHN patients, generated structural connectivity (SC) and functional connectivity (FC) networks, and assessed the corresponding clinical information assessment. Based on AAL(90) mapping, the brain network was divided into 9 modules, and the structural-functional connectivity (SC-FC) coupling was compared at the whole-brain level and within the modules, as well as alterations in the topological properties of the brain network in the patient group.
View Article and Find Full Text PDFEffect of Divalent Cations on Polarity and Hydration at the Lipid/Water Interface Probed by 4-Aminophthalimide-Based Dyes.
J Phys Chem B
January 2025
Spectroscopy Laboratory, School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
The ion binding to the lipid/water interface can substantially influence the structural, functional, and dynamic properties of the cell membrane. Despite extensive research on ion-lipid interactions, the specific effects of ion binding on the polarity and hydration at the lipid/water interface remain poorly understood. This study explores the influence of three biologically relevant divalent cations─Mg, Ca, and Zn─on the depth-dependent interfacial polarity and hydration of zwitterionic DPPC lipid in its gel phase at room temperature.
View Article and Find Full Text PDFTargeted Covalent Modification Strategies for Drugging the Undruggable Targets.
Chem Rev
January 2025
Graduate School of Engineering, Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
The term "undruggable" refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Drugging such undruggable targets is essential to develop new therapies for diseases where current treatment options are limited or nonexistent. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry.
View Article and Find Full Text PDFThe mechanisms of thermal processing techniques on modifying structural, functional and flour-processing properties of whole-grain highland barley.
Food Chem
December 2024
Glycomics and Glycan Bioengineering Research Center, College of Food Science &Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:
The mechanisms underlying three thermal processing methods, namely hot-air drying, microwave irradiation, and heat fluidization, were systematically investigated to evaluate their effects on the structural, functional, and flour-processing properties of whole-grain highland barley. Starch granules were partially damaged when treated with hot-air drying and microwave irradiation. However, these granules were predominantly aggregated or encapsulated in proteins following heat fluidization.
View Article and Find Full Text PDFConnectome embedding in multidimensional graph spaces.
Netw Neurosci
December 2024
Department of Psychology and Neuroscience, Auckland University of Technology, Auckland, New Zealand.
Connectomes' topological organization can be quantified using graph theory. Here, we investigated brain networks in higher dimensional spaces defined by up to 10 graph theoretic nodal properties. These properties assign a score to nodes, reflecting their meaning in the network.
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