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Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy.
Psychoradiology
December 2024
Department of Neurology, the First Hospital of Anhui Medical University, Hefei 230022, China.
Background: The hippocampus has been widely reported to be involved in the neuropathology of major depressive disorder (MDD). All the previous researches adopted group-level hippocampus subregions atlas to investigate abnormal functional connectivities in MDD in absence of capturing individual variability. In addition, the molecular basis of functional impairments of hippocampal subregions in MDD remains elusive.
View Article and Find Full Text PDFAlterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study.
Front Neurol
January 2025
School of Public Health, Shanxi Medical University, Taiyuan, China.
Background: Cognitive impairment (CI) is a condition in which an individual experiences noticeable impairment in thinking abilities. Long-term exposure to aluminum (Al) can cause CI. This study aimed to determine the relationship between CI and MRI-related changes in postroom workers exposed to Al.
View Article and Find Full Text PDFPlastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report.
Front Psychiatry
January 2025
Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Bipolar disorder (BD) is a prevalent mood disorder characterized by alternating episodes of depression and mania, often accompanied by varying degrees of cognitive impairment. Cognitive impairments often serve as indicators of a bleak prognosis or the likelihood of progressing to dementia. Additionally, some studies suggest that individuals diagnosed with BD may undergo a decline in hippocampal volume.
View Article and Find Full Text PDFVitamin K2 protects against D-galactose induced ageing in mice.
Eur J Pharmacol
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata. Electronic address:
Background: Ageing is a complex process characterized by the gradual deterioration of physiological functions, often leading to a diminished quality of life. Dementia is among the prominent indicators of ageing characterized by cognitive impairment. Animal studies employing D-galactose have provided insights into the mechanisms underlying cognitive decline and neuronal degeneration, resembling features of human brain ageing while Vitamin K2, known for its diverse physiological functions, also have neuroprotective potential.
View Article and Find Full Text PDFClosed-loop modulation of remote hippocampal representations with neurofeedback.
Neuron
January 2025
Kavli Institute and Department of Physiology, UCSF, San Francisco, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address:
Humans can remember specific remote events without acting on them and influence which memories are retrieved based on internal goals. However, animal models typically present sensory cues to trigger memory retrieval and then assess retrieval based on action. Thus, it is difficult to determine whether measured neural activity patterns relate to the cue(s), the memory, or the behavior.
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