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The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus.
PLoS Pathog
December 2024
The Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom.
Virus assembly is a crucial step for the completion of the viral replication cycle. In addition to ensuring efficient incorporation of viral genomes into nascent virions, high specificity is required to prevent incorporation of host nucleic acids. For picornaviruses, including FMDV, the mechanisms required to fulfil these requirements are not well understood.
View Article and Find Full Text PDFGenome-wide analysis reveals that the cytochrome P450 family 7 subfamily B member 1 gene is implicated in growth traits in Rasa Aragonesa ewes.
Animal
October 2023
Departamento de Ciencia Animal, Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA-IA2), Avda. Montañana 930, 50059 Zaragoza, Spain; Aragonese Foundation for Research and Development (ARAID), 50018 Zaragoza, Spain.
Sheep are very well adapted to changing environments and are able to produce and reproduce with low inputs in feed and water better than other domestic ruminants. Indeed, the ewe body condition score (BCS) and live weight (LW) play a significant role in productive and reproductive performance. This work conducts a genome-wide association study (GWAS) to detect genetic variants associated with growth traits in 225 adult ewes of the Rasa Aragonesa breed by using the genotypes from 50 k and HD Illumina Ovine BeadChip.
View Article and Find Full Text PDFNovel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Macromeront Formation.
Front Cell Infect Microbiol
April 2022
Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.
Apicomplexan parasites are considered as defective in cholesterol synthesis. Consequently, they need to scavenge cholesterol from the host cell by either enhancing the uptake of extracellular cholesterol sources or by upregulating host cellular biosynthesis. Given that macromeront formation in bovine lymphatic endothelial host cells is a highly cholesterol-demanding process, we here examined host parasite interactions based on host cellular uptake of different low-density lipoprotein (LDL) types, i.
View Article and Find Full Text PDFCircular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
J Clin Invest
December 2021
Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, China.
Circular RNAs (circRNAs) have been recently recognized as playing a role in the pathogenesis of vascular remodeling-related diseases by modulating the functions of miRNAs. However, the interplay between circRNAs and proteins during vascular remodeling remains poorly understood. Here, we investigated a previously identified circRNA, circEsyt2, whose expression is known to be upregulated during vascular remodeling.
View Article and Find Full Text PDFThe long-lasting enigma of polycytidine (polyC) tract.
PLoS Pathog
August 2021
Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Long polycytidine (polyC) tracts varying in length from 50 to 400 nucleotides were first described in the 5'-noncoding region (NCR) of genomes of picornaviruses belonging to the Cardio- and Aphthovirus genera over 50 years ago, but the molecular basis of their function is still unknown. Truncation or complete deletion of the polyC tracts in picornaviruses compromises virulence and pathogenicity but do not affect replicative fitness in vitro, suggesting a role as "viral security" RNA element. The evidence available suggests that the presence of a long polyC tract is required for replication in immune cells, which impacts viral distribution and targeting, and, consequently, pathogenic progression.
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