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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis.
Sci China Life Sci
January 2025
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Article Synopsis
- The study investigates how the tumor suppressor p53 affects the effectiveness of the WEE1 inhibitor AZD1775 in promoting ferroptosis, a type of cell death, in lung cancer cells.
- AZD1775 inhibits cystine uptake, which is crucial for ferroptosis, and leads to increased expression of SLC7A11, a resistance factor, by altering histone modifications via the WEE1-SETDB1 pathway.
- Combining AZD1775 with the nucleolar stress inducer Actinomycin D enhances the ability to induce ferroptosis and suppress lung cancer growth, particularly in cells with functional p53.
Circular RNA circ_GLIS2 suppresses hepatocellular carcinoma growth and metastasis.
Liver Int
March 2022
Department of Infectious Disease, The Third Xiangya Hospital, Central South University, Changsha, China.
Background & Aims: Hepatocellular carcinoma (HCC) is one of the leading causes of tumour-related death. Here, we investigated the molecular mechanism of HCC by studying the function of circ_GLIS2.
Methods: Human HCC specimens and cell lines were used.
Late hepatic toxicity surveillance for survivors of childhood, adolescent and young adult cancer: Recommendations from the international late effects of childhood cancer guideline harmonization group.
Cancer Treat Rev
November 2021
Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Background: Survivors of childhood, adolescent and young adult (CAYA) cancer may develop treatment-induced chronic liver disease. Surveillance guidelines can improve survivors' health outcomes. However, current recommendations vary, leading to uncertainty about optimal screening.
View Article and Find Full Text PDFA positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis.
BMC Cancer
June 2021
Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan Province, China.
Background: Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification in WDR5-dependent manner to involve in HBV infection and contribute to oncogene expression.
View Article and Find Full Text PDFLong non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma.
Exp Mol Pathol
June 2021
Department of hepatobiliary surgery, the First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, No.61 Jiefang West Road, Changsha City, Hunan Province 410005, China. Electronic address:
Backgrounds/aims: Hepatocellular carcinoma is recognized as the most common subtype of hepatic cancer. Muskelin 1 antisense RNA (MKLN1-AS) shows prognostic value in hepatitis B virus-hepatocellular carcinoma. The aim of this study is to investigate the detailed biological role of MKLN1-AS and Yes-associated transcriptional regulator 1 (YAP1)-related mechanisms.
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