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Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling.
iScience
February 2025
Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
The vagus nerve is proposed to enable communication between the gut microbiome and the brain, but activity-based evidence is lacking. We find that mice reared germ-free exhibit decreased vagal tone relative to colonized controls, which is reversed via microbiota restoration. Perfusing antibiotics into the small intestines of conventional mice, but not germ-free mice, acutely decreases vagal activity which is restored upon re-perfusion with intestinal filtrates from conventional, but not germ-free, mice.
View Article and Find Full Text PDFThis article conducts a comparative study of the complexity reduction of neural network (NN) models for nonlinearity compensation used in digital subcarrier multiplexing (DSCM)-based optical communication systems. We employ the NN model based on bi-directional long short-term memory (biLSTM) and 1D-convolutional NN (1D-CNN) layers. To reduce the computation complexity of the proposed solution, weight clustering is applied to the NN.
View Article and Find Full Text PDFValidity and reliability of the Turkish version of the Innsbruck RBD-9 diagnostic inventory (IRBD-9-TR).
Arq Neuropsiquiatr
January 2025
Istanbul University-Cerrahpasa Faculty of Medicine, Department of Neurology, Division of Clinical Neurophysiology, Istanbul, Turkey.
Background: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by loss of the normal atonia of REM sleep accompanied by repetitive motor and behavior phenomena of dream content.
Objective: To evaluate the reliability and validity of the Turkish version of the original form of the Innsbruck Rapid Eye Movement Sleep Behavior Disorder Diagnostic Inventory (IRBD-9) scale (IRBD-9-TR) and ensure that this screening test can be easily used in the Turkish language.
Methods: The present is a multicenter and prospective study involving 184 patients: 51 with iRBD and 133 healthy controls.
The Development of an Instagram Reel-Based Bystander Intervention Message Among College Students: Formative Survey and Mixed Methods Pilot Study.
JMIR Form Res
January 2025
College of Communication, DePaul University, Daley Bldg, 14 E Jackson Blvd, Chicago, IL, 60605, United States, 1 (312) 362-8600.
Background: Bystander intervention is a common method to address the ubiquitous issue that is sexual violence across college campuses. Short messages that incentivize bystander intervention behavior can be another tool to fight sexual violence.
Objective: This study aimed to conduct formative research surrounding social norms and bystander barriers to pilot and develop Instagram (Meta) reel-based messages addressing bystander intervention among college students.
Meeting Parents' Health Literacy Needs-Designing and Feasibility Testing of a Three-Step Intervention in the Childhood Epilepsy Context.
J Clin Nurs
January 2025
Department for Postgraduate Studies, Lovisenberg Diaconal University College, Oslo, Norway.
Aims: (1) To codesign a health literacy intervention within a specialist healthcare setting to help the parents of children with epilepsy access, comprehend, use and communicate information and (2) to assess the intervention's feasibility by exploring stakeholders' perspectives on its usefulness, ease of use of trial methods and contextual factors impacting its execution.
Design: A codesign participatory approach followed by a feasibility approach inspired by the OPtimising HEalth LIteracy and Access to Health Services (Ophelia) process for health literacy intervention development.
Methods: (1) The codesign approach included workshops with (a) multidisciplinary personnel (n = 9) and (b) parents (n = 12), along with (c) an interview with one regional epilepsy specialist nurse (n = 1).
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