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Safety and efficacy of melatonin supplementation as an add-on treatment for infantile epileptic spasms syndrome: A randomized, placebo-controlled, double-blind trial.
J Pineal Res
January 2024
Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
This was a prospective, randomized, double-blind, single-center placebo-controlled trial to assess the efficacy and safety of melatonin as an add-on treatment for infantile epileptic spasms syndrome (IESS). Participants aged 3 months to 2 years with a primary diagnosis of IESS were recruited and assigned to two groups in a 1:1 ratio. Both treatment groups received a combination of adrenocorticotrophic hormone (ACTH) and magnesium sulfate (MgSO ) for 2 weeks, and the treatment group also received melatonin (3 mg) between 20:00 and 21:00 daily, 0.
View Article and Find Full Text PDFThe diagnosis and management of Cushing's syndrome in pregnancy.
J Neuroendocrinol
August 2022
Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Endogenous Cushing's syndrome (CS) is rarely encountered during pregnancy. Clinical and biochemical changes in healthy pregnancy overlap with those seen in pregnancy complicated by CS; the diagnosis is therefore challenging and can be delayed. During normal gestation, adrenocorticotrophic hormone, corticotrophin-releasing hormone, cortisol, and urinary free cortisol levels rise.
View Article and Find Full Text PDFNursing intervention using a whole-process escort playing a relative role combined with mind mapping in patients undergoing breast cancer surgery: a randomized trial.
Ann Palliat Med
December 2021
Nursing Department, Wuhan Wuchang Hospital, Wuhan, China.
Background: Breast cancer is the most common malignant tumor affecting women worldwide. Surgery is the main treatment for breast cancer and can obtain a good curative effect. However, it can also entail trauma and stress for patients, leaving them susceptible to negative emotions, poor sleep quality, and various postoperative complications, which can affect the treatment effect and prognosis.
View Article and Find Full Text PDFTargeting the Oxytocin System to Ameliorate Early Life Depressive-Like Behaviors in Maternally-Separated Rats.
Biol Pharm Bull
October 2021
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University.
Oxytocin (OXT) -"the love hormone"- has been involved in the anti-depressant activity of some selective serotonin reuptake inhibitors (SSRIs). The exact mechanism underlying the OXT pathway in depression is not fully clear. This study aimed to investigate the effect of OXT analogue, carbetocin (CBT) and the SSRI, escitalopram (ESCIT) on depressive-like behaviors following maternal separation (MS).
View Article and Find Full Text PDFThe Effects of At-Birth Adoption on Atypical Behavior and Anxiety: A Nonhuman Primate Model.
J Am Acad Child Adolesc Psychiatry
November 2021
Brigham Young University, Provo, Utah. Electronic address:
Objective: Adopted children tend to show an increased risk for a variety of psychopathological outcomes, even when adoption occurs at birth, which some suggest is a result of nonrandom assignment of adoptees and parents. This study uses a nonhuman primate model, in which adoptions were randomly assigned, to investigate the behavioral and physiological outcomes associated with at-birth adoption.
Method: Immediately following birth, rhesus monkey infants were randomly assigned to be reared by either their biological mother (n = 113) or by an unrelated, lactating, adoptive mother (n = 34).
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