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Nanoparticles (NPs)-mediated silencing of GSTP1 expression to reverse chemoresistance for effective breast cancer therapy.
J Colloid Interface Sci
January 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, PR China; Guangzhou Key Laboratory of Medical Nanomaterials, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, PR China. Electronic address:
Chemotherapy remains the primary treatment modality for breast cancer (BCa) patients. However, chemoresistance commonly arises in clinical settings, contributing to poor prognosis. The development of chemoresistance is a dynamic and complex process involving the activation of oncogenes and inactivation of tumor suppressor genes.
View Article and Find Full Text PDFChronic alcohol consumption aggravates acute kidney injury through integrin β1/JNK signaling.
Redox Biol
November 2024
State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; National Clinical Research Center of Kidney Disease, Guangdong Provincial Institute of Nephrology, Guangzhou, China. Electronic address:
Article Synopsis
- Alcohol abuse is linked to multiple health issues, with this study focusing on how it affects acute kidney injury (AKI), revealing that it worsens AKI in female mice but not in males.
- The study found that chronic and binge alcohol consumption led to more severe kidney dysfunction and cell damage (apoptosis) in female mice after kidney injury compared to control groups.
- Key mechanisms identified include the activation of integrin β1 and JNK signaling pathways, and the role of acetaldehyde, a byproduct of alcohol metabolism, which increases the severity of AKI in female mice.
Extracellular Vesicle Inhibitors Enhance Cholix-Induced Cell Death via Regulation of the JNK-Dependent Pathway.
Toxins (Basel)
August 2024
Laboratory of Microbiology and Infection Control, Division of Biological Sciences, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.
is an important foodborne pathogen. Cholix cytotoxin (Cholix), produced by , is a novel eukaryotic elongation factor 2 (eEF2) adenosine diphosphate ribosyltransferase that causes host cell death by inhibiting protein synthesis. However, the role of Cholix in the infectious diseases caused by remains unclear.
View Article and Find Full Text PDFαvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8.
BMC Biotechnol
May 2022
College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Background: Small extracellular vesicles (sEVs) are nanometer-sized membranous particles shed by many types of cells and can transfer a multitude of cargos between cells. Recent studies of sEVs have been focusing on their potential to be novel drug carriers due to natural composition and other promising characteristics. However, there are challenges in sEVs-based drug delivery, one of which is the inefficient loading of drugs into sEVs, especially for large biomolecules.
View Article and Find Full Text PDFPathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis.
Int J Mol Sci
June 2021
Department of Biomedical Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Idiopathic pulmonary fibrosis (IPF) is one of the most symptomatic progressive fibrotic lung diseases, in which patients have an extremely poor prognosis. Therefore, understanding the precise molecular mechanisms underlying pulmonary fibrosis is necessary for the development of new therapeutic options. Stress-activated protein kinases (SAPKs), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38) are ubiquitously expressed in various types of cells and activated in response to cellular environmental stresses, including inflammatory and apoptotic stimuli.
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