Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00493308 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
G-protein-coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca and sarcomere shortening.
FASEB J
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G-protein-coupled receptor 41 (GPR41) is a Gα-coupled receptor activated by short-chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild-type (WT) and GPR41 knockout (GPR41) adult mice and intracellular Ca concentration and cell shortening were measured using the IonOptix system.
View Article and Find Full Text PDFStenotrophomonas maltophilia uses a c-di-GMP module to sense the mammalian body temperature during infection.
PLoS Pathog
September 2024
State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
The body temperature of Warm-blooded hosts impedes and informs responses of bacteria accustomed to cooler environments. The second messenger c-di-GMP modulates bacterial behavior in response to diverse, yet largely undiscovered, stimuli. A long-standing debate persists regarding whether a local or a global c-di-GMP pool plays a critical role.
View Article and Find Full Text PDFThe HmrABCX pathway regulates the transition between motile and sessile lifestyles in by a mechanism independent of transcription.
mBio
October 2024
Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Quebec, Canada.
Unlabelled: During its cell cycle, the bacterium switches from a motile, free-living state, to a sessile surface-attached cell. During this coordinated process, cells undergo irreversible morphological changes, such as shedding of their polar flagellum and synthesis of an adhesive holdfast at the same pole. In this work, we used genetic screens to identify genes involved in the regulation of the transition from the motile to the sessile lifestyle.
View Article and Find Full Text PDF[Cyclic nucleotide phosphodiesterases: therapeutic targets in cardiac hypertrophy and failure].
Med Sci (Paris)
July 2024
Université Paris-Saclay, Inserm UMR-S 1180, Orsay, France.
Cyclic nucleotide phosphodiesterases (PDEs) modulate neurohormonal regulation of cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple isoforms of PDEs with different enzymatic properties and subcellular locally regulate cyclic nucleotide levels and associated cellular functions. This organisation is severely disrupted during hypertrophy and heart failure (HF), which may contribute to disease progression.
View Article and Find Full Text PDFPhosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease.
Neurochem Res
August 2024
Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271016, Shandong, China.
Article Synopsis
- Phosphodiesterase 8 (PDE8) is important for breaking down cAMP in the brain and is being studied for its potential link to Alzheimer's disease (AD).
- Research on C57BL/6J mice showed that both PDE8A and PDE8B are present in various brain regions, especially those related to cognition, without significant differences between males and females.
- In triple transgenic AD mice, PDE8A expression in the hippocampus increased with age for both sexes, while PDE8B showed an age-related increase only in the cerebral cortex of female mice.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!