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Regulatory effects of baicalin, a flavonoid compound, on adipocyte metabolism.
J Physiol Pharmacol
August 2023
Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, Poznan, Poland.
Baicalin is a plant-derived, biologically active compound exerting numerous advantageous effects. Adipocytes store and release energy in the process of lipogenesis and lipolysis. Rodent studies have shown that baicalin treatment positively affects fat tissue, however, data on the direct influence of this compound on adipocyte metabolism is lacking.
View Article and Find Full Text PDFRecurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat.
Metabolism
November 2022
Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, China. Electronic address:
Introduction: Recurrent hypoglycemia (RH) impairs secretion of counterregulatory hormones. Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory hormones are poorly understood.
Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation within liver, white adipose tissue and skeletal muscle.
L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cells.
Nutr Res Pract
October 2021
Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon 14662, Korea.
Background/objectives: L. (guava) leaves have been shown to exhibit hypoglycemic and antidiabetic effects in rodents. This study investigated the effects of guava leaf extract on adipogenesis, glucose uptake, and lipolysis of adipocytes to examine whether the antidiabetic properties are mediated through direct effects on adipocytes.
View Article and Find Full Text PDFHemin attenuates response of primary rat adipocytes to adrenergic stimulation.
PeerJ
September 2021
Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland.
Hemin is an activator of heme oxygenase-1 (HO-1), an enzyme catalyzing heme degradation. Up-regulation of HO-1 is observed in response to various pathological conditions. Moreover, pharmacological activation of HO-1 is associated with numerous beneficial effects in the organism.
View Article and Find Full Text PDFEffects of short-term fasting and pharmacological activation of AMPK on metabolism of rat adipocytes.
Arch Physiol Biochem
February 2021
Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Poznan, Poland.
AMP-activated protein kinase (AMPK) is a key intracellular energy sensor and regulates processes associated with energy metabolism. In the present study, effects of AICAR, a pharmacological activator of AMPK, on metabolism of adipocytes of non-fasted and 12-h fasted rats were compared. It was shown that in fat cells of control rats, epinephrine- and dibutyryl-cAMP-induced lipolysis was markedly reduced in the presence of AICAR.
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