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Baseline Ga-68 PSMA PET-Derived Primary Tumor Parameters in Patients with Prostate Cancer and Their Association with Clinical Risk Stratification and Clinicopathologic Features.
World J Nucl Med
December 2024
Department of Nuclear Medicine, Atatürk Training and Research Hospital, İzmir Kâtip Çelebi University, Izmir, Türkiye.
This article evaluates whether parameters derived from the gallium-68-labeled prostate-specific membrane antigen ( Ga-PSMA) positron emission tomography/computed tomography (PET/CT) imaging studies of primary prostate cancer (PCa) lesions were associated with Gleason score (GS), D'Amico risk class, Candiolo nomograms, and the metastatic status of the disease. We retrospectively evaluated newly diagnosed PCa patients who underwent Ga-PSMA PET/CT before therapy. Age, baseline serum prostate-specific antigen (PSA), and metastatic status were recorded.
View Article and Find Full Text PDFFanconi syndrome following administration of oral supplements containing red yeast rice: several months follow-up of three cases.
CEN Case Rep
December 2024
Department of Nephrology, Faculty of Medicine, Juntendo University, 3-1-3 Hongou, Bunkyo-ku, Tokyo, 133-8431, Japan.
Article Synopsis
- The long-term effects and treatment of acute kidney injury (AKI) from the red yeast rice supplement Benikoji CholesteHelp are not fully understood, but three cases of renal dysfunction improved after stopping the supplement.
- In the first case, a 59-year-old woman developed severe renal impairment and Fanconi syndrome after 7 months of use, but her kidney function gradually improved over three months post-discontinuation, though not back to baseline levels.
- The other two cases involved men aged 48 and 47 who experienced mild renal dysfunction after taking the supplement for 2 and 4 months, respectively, both of which showed significant improvement after stopping the supplement, indicating that discontinuation may reverse renal impairment in these scenarios.
Development of a homotrimeric PSMA radioligand based on the NOTI chelating platform.
EJNMMI Radiopharm Chem
December 2024
Department of Nuclear Medicine, Saarland University - Medical Center, Kirrbergerstrasse, 66421, Homburg, Germany.
Background: The NOTI chelating scaffold can readily be derivatized for bioconjugation without impacting its metal complexation/radiolabeling properties making it an attractive building block for the development of multimeric/-valent radiopharmaceuticals. The objective of the study was to further explore the potential of the NOTI chelating platform by preparing and characterizing homotrimeric PSMA radioconjugates in order to identify a suitable candidate for clinical translation.
Results: Altogether, three PSMA conjugates based on the NOTI-TVA scaffold with different spacer entities between the chelating unit and the Glu-CO-Lys PSMA binding motif were readily prepared by solid phase-peptide chemistry.
αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using Ga-Trivehexin.
Front Nucl Med
November 2024
Department of Nuclear Medicine, University Hospital Dresden, Technische Universität Dresden (TUD), Dresden, Germany.
Purpose: Ga-Trivehexin is a PET tracer targeting αvβ6-integrin, a transmembrane receptor that is frequently expressed by pancreatic cancer cells. This study aimed to determine the biokinetics, image contrast, and acquisition parameters for Ga-Trivehexin PET imaging in pancreatic cancers.
Methods: 44 patients with pancreatic cancer underwent Trivehexin PET/CT between June 2021 and November 2022 (EK-242052023).
Positron Emission Tomography Imaging of Cathepsin B in Tumors with Activable Small Molecule Tracers.
J Med Chem
December 2024
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.
Cathepsin B (CTB) is overexpressed in several types of tumors, and precise evaluation of the CTB activity can offer a promising method for the early diagnosis of tumors. In this study, two CTB-activated positron emission tomography (PET) tracers, and , were developed for sensitive and specific detection of CTB. Both tracers undergo a click condensation between 2-cyano-6-aminobenzothiazole (CBT) and cysteine (Cys) to form a cyclization product, thereby enhancing and prolonging the PET signal in tumors.
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